This contract is one part of the pre-clinical portion of the NIAID Antiviral Substances Program. The Program supports six separate awards to investigators who have developed animal models of viral infections which can be used to test the activity of antiviral agents in vivo. Compounds are evaluated for efficacy both therapeutically and prophylactically. Studies of drug toxicity and effects of drug treatment on the immune response to infection are also pursued. Combination chemotherapy studies are encouraged. The currently awarded series of contractors have at their disposal the following models: University of Alabama - herpes encephalitis in the mouse, neonatal herpes in the mouse, genital herpes in the guinea pig, murine cytomegalovirus in the mouse; Utah State University - influenza in the mouse; Baylor College of Medicine - respiratory syncytial, parainfluenza and measles viruses in the cotton rat; Massachusetts Eye Research Institute, varicella-zoster virus and human cytomegalovirus in the rabbit; Cincinnati Children's Hospital - genital herpes, neonatal herpes and cytomegalovirus in the guinea pig; and, University of Texas at Galveston - coxsackievirus in the mouse.

Project Start
1990-11-30
Project End
1995-11-29
Budget Start
1994-11-28
Budget End
1995-11-29
Support Year
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Utah State University
Department
Veterinary Sciences
Type
Schools of Earth Sciences/Natur
DUNS #
City
Logan
State
UT
Country
United States
Zip Code
84322
Sidwell, R W; Smee, D F (2000) In vitro and in vivo assay systems for study of influenza virus inhibitors. Antiviral Res 48:16-Jan
Sidwell, R W; Huffman, J H; Barnard, D L et al. (1998) Inhibition of influenza virus infections in mice by GS4104, an orally effective influenza virus neuraminidase inhibitor. Antiviral Res 37:107-20
Sidwell, R W; Bailey, K W; Wong, M H et al. (1995) In vitro and in vivo sensitivity of a non-mouse-adapted influenza A (Beijing) virus infection to amantadine and ribavirin. Chemotherapy 41:455-61
Sidwell, R W; Smee, D F; Huffman, J H et al. (1995) Antiviral activity of an immunomodulatory lipophilic desmuramyl dipeptide analog. Antiviral Res 26:145-59
Sidwell, R W; Huffman, J H; Moscon, B J et al. (1994) Influenza virus-inhibitory effects of intraperitoneally and aerosol-administered SP-303, a plant flavonoid. Chemotherapy 40:42-50
Sidwell, R W; Huffman, J H; Gilbert, J et al. (1992) Utilization of pulse oximetry for the study of the inhibitory effects of antiviral agents on influenza virus in mice. Antimicrob Agents Chemother 36:473-6