Current therapies to treat opportunistic infections associated with the Acquired Immunedeficiency Syndrome (AIDS) are either highly toxic, extremely expensive or marginally effective. In addition, there is no therapy recognized as effective for certain of the pathogens. Because present therapies produce toxic reactions in a large percentage of patients, the availability of alternative therapeutics is of upmost importance since these infections produce significant morbidity and mortality in patients with AIDS, the National Institute of Allergy and Infectious Diseases (NIAID) has funded several programs to facilitate drug development efforts against opportunistic infections by providing contract resources for efficacy evaluations in animals, a critical component in new drug approval. The availability of animal model testing systems will provide the NIAID with testing capabilities to evaluate therapies for treatment against pathogenic fungi (Candida albicans, Cryptococcus neoformans, Histoplasma capsulatum), and determine the pharmacokinetics and toxicities of the experimental therapies. This will permit the submission of the resulting data in support of an IND application for the new therapy. The contractor will have the capability to evaluate therapeutic agents in small animal (in vivo) and culture (in vitro) model test systems, develop alternative protocols to accommodate special characteristics of individual therapies or model test systems, measure general toxicity, determine pharmacokinetic parameters, etc, to assist the sponsor in the development of new therapies against pathogenic fungi.
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| Graybill, J R; Bocanegra, R; Fothergill, A et al. (1996) Bleomycin therapy of experimental disseminated candidiasis in mice. Antimicrob Agents Chemother 40:816-8 |
| Graybill, J R; Bocanegra, R; Luther, M (1995) Antifungal combination therapy with granulocyte colony-stimulating factor and fluconazole in experimental disseminated candidiasis. Eur J Clin Microbiol Infect Dis 14:700-3 |
