Abstract

The National institute of Allergy and Infectious Diseases (NIAID) has a requirement to develop a resource for tuberculosis researchers which will supply their needs for a constant source of research materials that are of consistently high quality. Such a resource will be an important factor in the advancement of tuberculosis research efforts and will be a factor in ensuring that research results from different laboratories will be reproducible. Therefore, it is necessary to develop and utilize an experimental animal model of tuberculosis; to identify and provide the major carbohydrate antigens of virulent strains of tuberculosis; to develop a skin test reagent; to test promising reagents in an animal model; to develop a protein antigen bank and corresponding antibodies from virulent tuberculosis; to prepare and distribute to investigators highly purified mycobacterial carbohydrates from virulent tuberculosis, to propagate and distribute virulent tuberculosis cells to supply investigators needs; and to provide and distribute to investigators purified DNA and R-NA preparations from virulent tuberculosis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research and Development Contracts (N01)
Project #
N01AI025147-011
Application #
2295527
Study Section
Project Start
1992-07-01
Project End
1996-06-30
Budget Start
1995-01-04
Budget End
1996-06-30
Support Year
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Colorado State University-Fort Collins
Department
Microbiology/Immun/Virology
Type
Schools of Arts and Sciences
DUNS #
112617480
City
Fort Collins
State
CO
Country
United States
Zip Code
80523

  Publications

Anderson, Elizabeth J; Webb, Emily L; Mawa, Patrice A et al. (2012) The influence of BCG vaccine strain on mycobacteria-specific and non-specific immune responses in a prospective cohort of infants in Uganda. Vaccine 30:2083-9
Ndibazza, Juliet; Mpairwe, Harriet; Webb, Emily L et al. (2012) Impact of anthelminthic treatment in pregnancy and childhood on immunisations, infections and eczema in childhood: a randomised controlled trial. PLoS One 7:e50325
Webb, Emily L; Mawa, Patrice A; Ndibazza, Juliet et al. (2011) Effect of single-dose anthelmintic treatment during pregnancy on an infant's response to immunisation and on susceptibility to infectious diseases in infancy: a randomised, double-blind, placebo-controlled trial. Lancet 377:52-62
Elliott, Alison M; Mawa, Patrice A; Webb, Emily L et al. (2010) Effects of maternal and infant co-infections, and of maternal immunisation, on the infant response to BCG and tetanus immunisation. Vaccine 29:247-55
de Chastellier, Chantal; Forquet, Frederique; Gordon, Alon et al. (2009) Mycobacterium requires an all-around closely apposing phagosome membrane to maintain the maturation block and this apposition is re-established when it rescues itself from phagolysosomes. Cell Microbiol 11:1190-207
Garton, Natalie J; Sutcliffe, Iain C (2006) Identification of a lipoarabinomannan-like lipoglycan in the actinomycete Gordonia bronchialis. Arch Microbiol 184:425-7
Elliott, Alison M; Namujju, Proscovia B; Mawa, Patrice A et al. (2005) A randomised controlled trial of the effects of albendazole in pregnancy on maternal responses to mycobacterial antigens and infant responses to Bacille Calmette-Guerin (BCG) immunisation [ISRCTN32849447]. BMC Infect Dis 5:115
Gilleron, Martine; Garton, Natalie J; Nigou, Jerome et al. (2005) Characterization of a truncated lipoarabinomannan from the Actinomycete Turicella otitidis. J Bacteriol 187:854-61
Garton, Natalie J; Gilleron, Martine; Brando, Therese et al. (2002) A novel lipoarabinomannan from the equine pathogen Rhodococcus equi. Structure and effect on macrophage cytokine production. J Biol Chem 277:31722-33
Lodes, M J; Dillon, D C; Mohamath, R et al. (2001) Serological expression cloning and immunological evaluation of MTB48, a novel Mycobacterium tuberculosis antigen. J Clin Microbiol 39:2485-93

Showing the most recent 10 out of 27 publications