The objective of this contract is to utilize appropriate papillomavirus animal model systems to evaluate the efficacy of experimental antiviral substance to control papillomavirus infections. In addition, the models will be studied to provide badly needed information on the natural history and pathogenesis of papillomavirus infections. This infection not only has a serious detrimental impact on the infected individual's quality of life, but several types of the etiologic agent are almost certainly a cofactor in the development of cervical carcinoma which kills 7000 American women annually. None of the currently available therapies including interferon, 5-flurorouraul cryotherapy, laser surgery and podophyllotoxin are adequate. In 1988, NIAID awarded two contracts for the evaluation of experimental therapies. As a result of these studies, several compounds have been identifies which warrant clinical evaluation. Further preclinical study of other compounds are targeted towards the support of clinical development in the near future. This contract will assure continuation of this vital resource for the development of antiviral therapies.

Project Start
1993-03-01
Project End
1996-02-28
Budget Start
1994-10-26
Budget End
1996-02-28
Support Year
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Pathology
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033
Zeitlin, L; Hoen, T E; Achilles, S L et al. (2001) Tests of Buffergel for contraception and prevention of sexually transmitted diseases in animal models. Sex Transm Dis 28:417-23
Hagari, Y; Budgeon, L R; Pickel, M D et al. (1995) Association of tumor necrosis factor-alpha gene expression and apoptotic cell death with regression of Shope papillomas. J Invest Dermatol 104:526-9