Project Start
1993-09-30
Project End
1998-09-29
Budget Start
1997-03-28
Budget End
1998-09-29
Support Year
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Utah State University
Department
Veterinary Sciences
Type
Schools of Earth Sciences/Natur
DUNS #
City
Logan
State
UT
Country
United States
Zip Code
84322
Mangel, W F; Brown, M T; Baniecki, M L et al. (2001) Prevention of viral drug resistance by novel combination therapy. Curr Opin Investig Drugs 2:613-6
Mangel, W F; McGrath, W J; Brown, M T et al. (2001) A new form of antiviral combination therapy predicted to prevent resistance from arising, and a model system to test it. Curr Med Chem 8:933-9
Barnard, D L; Sidwell, R W; Xiao, W et al. (1999) 2-5A-DNA conjugate inhibition of respiratory syncytial virus replication: effects of oligonucleotide structure modifications and RNA target site selection. Antiviral Res 41:119-34
Lin, Y M; Flavin, M T; Schure, R et al. (1999) Antiviral activities of biflavonoids. Planta Med 65:120-5
Player, M R; Barnard, D L; Torrence, P F (1998) Potent inhibition of respiratory syncytial virus replication using a 2-5A-antisense chimera targeted to signals within the virus genomic RNA. Proc Natl Acad Sci U S A 95:8874-9
Sidwell, R W; Huffman, J H; Barnard, D L et al. (1998) Inhibition of influenza virus infections in mice by GS4104, an orally effective influenza virus neuraminidase inhibitor. Antiviral Res 37:107-20
Tai, C Y; Escarpe, P A; Sidwell, R W et al. (1998) Characterization of human influenza virus variants selected in vitro in the presence of the neuraminidase inhibitor GS 4071. Antimicrob Agents Chemother 42:3234-41
Mendel, D B; Tai, C Y; Escarpe, P A et al. (1998) Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection. Antimicrob Agents Chemother 42:640-6
Barnard, D L; Hill, C L; Gage, T et al. (1997) Potent inhibition of respiratory syncytial virus by polyoxometalates of several structural classes. Antiviral Res 34:27-37