Discover new antifungal agents with potential utility specifically for the treatment of disseminated Candidiasis, a common opportunistic infection in immunocompromised individuals. This goal will be accomplished by the initial in vitroevaluation of anti-Candidal activity of extracts of higher plants and microorganisms. Pure antifungal compounds will beisolated with the aid of a bioassay-directed fractionation and purification scheme. The pure antifungal agents will be evaluated in vivo for efficacy, toxicity, synergism, and their effect on the immune system using a mouse model of disseminated Candidiasis.
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| Adeoye, A O; Oguntimein, B O; Clark, A M et al. (1986) 3-Dimethylallylindole: an antibacterial and antifungal metabolite from Monodora tenuifolia. J Nat Prod 49:534-7 |
