Project Start
1994-03-01
Project End
1999-02-28
Budget Start
1994-10-31
Budget End
1996-02-28
Support Year
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Harvard University
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Cambridge
State
MA
Country
United States
Zip Code
02138
Re, Fabio; Strominger, Jack L (2002) Monomeric recombinant MD-2 binds toll-like receptor 4 tightly and confers lipopolysaccharide responsiveness. J Biol Chem 277:23427-32
Falk, Kirsten; Lau, Julie M; Santambrogio, Laura et al. (2002) Ligand exchange of major histocompatibility complex class II proteins is triggered by H-bond donor groups of small molecules. J Biol Chem 277:2709-15
Stienekemeier, M; Falk, K; Rotzschke, O et al. (2001) Vaccination, prevention, and treatment of experimental autoimmune neuritis (EAN) by an oligomerized T cell epitope. Proc Natl Acad Sci U S A 98:13872-7
Santambrogio, L; Belyanskaya, S L; Fischer, F R et al. (2001) Developmental plasticity of CNS microglia. Proc Natl Acad Sci U S A 98:6295-300
Falk, K; Rotzschke, O; Santambrogio, L et al. (2000) Induction and suppression of an autoimmune disease by oligomerized T cell epitopes: enhanced in vivo potency of encephalitogenic peptides. J Exp Med 191:717-30
Fridkis-Hareli, M; Rosloniec, E F; Fugger, L et al. (2000) Synthetic peptides that inhibit binding of the collagen type II 261-273 epitope to rheumatoid arthritis-associated HLA-DR1 and -DR4 molecules and collagen-specific T-cell responses. Hum Immunol 61:640-50
Falk, K; Rotzschke, O; Strominger, J L (2000) Antigen-specific elimination of T cells induced by oligomerized hemagglutinin (HA) 306-318. Eur J Immunol 30:3012-20
Rotzschke, O; Falk, K; Mack, J et al. (1999) Conformational variants of class II MHC/peptide complexes induced by N- and C-terminal extensions of minimal peptide epitopes. Proc Natl Acad Sci U S A 96:7445-50
Fridkis-Hareli, M; Neveu, J M; Robinson, R A et al. (1999) Binding motifs of copolymer 1 to multiple sclerosis- and rheumatoid arthritis-associated HLA-DR molecules. J Immunol 162:4697-704
Abraham, R S; Wilson, S B; de Souza Jr, N F et al. (1999) NOD background genes influence T cell responses to GAD 65 in HLA-DQ8 transgenic mice. Hum Immunol 60:583-90

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