Maintain nonhuman primates in biohazard containment facilities for studies of AIDS and selected human respiratory tract and enteric diseases. In addition, many technical procedures will be performed on the animals. Testing of various reassortant influenza viruses, human respiratory syncytial viruses, and rotaviruses will be done in squirrel monkeys, owl monkeys, chimpanzees, and rhesus monkeys. As an animal model of human AIDS, up to nine chimpanzees will be inoculated with selected human material, then monitored for clinical or hematological signs of disease. This investigation will be long-term, continuing for at least two years post inoculation. Studies with respiratory tract infections will primarily be focused on testing of candidate vaccine strains and will involve from four to twenty-two animals per study. Individual studies will likely not exceed two months in duration, and up to fourteen studies will beperformed each year.

Project Start
1985-01-01
Project End
1989-12-31
Budget Start
1986-11-13
Budget End
1987-12-31
Support Year
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Sema, Inc.
Department
Type
DUNS #
City
Rockville
State
MD
Country
United States
Zip Code
20850