Abstract

Evaluate candidate vaccines (viral or bacterial) in infants under one year of age and young children. Conduct, depending on the vaccine to be tested, Phase I studies in semi-closed or carefully monitored open populations of infantsand children. Determine, depending on the vaccine to be tested, the safety, infectivity, degree of virulence, reactogenicity, transmissibility, genetic stability, and immunogenicity. Follow vaccinees for two to three years to document any potential hazards of immunication, duration of antibody, and resistance in the event of natural challenge within the community. Initiate and maintain epidemiologic and laboratory surveillance for infection of the major viral pathogens of infancy and childhood in the population proposed for this study. Conduct appropriate assays for viral antigens and antibodies. Evaluate antiviral substance for prophylaxis and therapy of viral infections.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research and Development Contracts (N01)
Project #
N01AI052576-006
Application #
2296353
Study Section
Project Start
1985-02-01
Project End
1989-10-07
Budget Start
1987-09-11
Budget End
1987-10-07
Support Year
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Pediatrics
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37203

  Publications

Graham, B S; Bunton, L A; Wright, P F et al. (1991) Reinfection of mice with respiratory syncytial virus. J Med Virol 34:7-13
Montefiori, D C; Lefkowitz Jr, L B; Keller, R E et al. (1991) Absence of a clinical correlation for complement-mediated, infection-enhancing antibodies in plasma or sera from HIV-1-infected individuals. Multicenter AIDS Cohort Study Group. AIDS 5:513-7
Graham, B S; Bunton, L A; Wright, P F et al. (1991) Role of T lymphocyte subsets in the pathogenesis of primary infection and rechallenge with respiratory syncytial virus in mice. J Clin Invest 88:1026-33
Graham, B S; Bunton, L A; Rowland, J et al. (1991) Respiratory syncytial virus infection in anti-mu-treated mice. J Virol 65:4936-42
Tajima, T; Thompson, J; Wright, P F et al. (1990) Evaluation of a reassortant rhesus rotavirus vaccine in young children. Vaccine 8:70-4
Graham, B S; Rowland, J M; Modliszewski, A et al. (1990) Antifusion activity in sera from persons infected with human immunodeficiency virus type 1. J Clin Microbiol 28:2608-11
Robinson Jr, W E; Montefiori, D C; Mitchell, W M (1990) Complement-mediated antibody-dependent enhancement of HIV-1 infection requires CD4 and complement receptors. Virology 175:600-4
Graham, B S; Karzon, D T (1990) Development of an AIDS vaccine. Biological and ethical challenges. Infect Dis Clin North Am 4:223-43
Robinson Jr, W E; Montefiori, D C; Gillespie, D H et al. (1989) Complement-mediated, antibody-dependent enhancement of HIV-1 infection in vitro is characterized by increased protein and RNA syntheses and infectious virus release. J Acquir Immune Defic Syndr 2:33-42
Barbey-Morel, C L; Oeltmann, T N; Edwards, K M et al. (1987) Role of respiratory tract proteases in infectivity of influenza A virus. J Infect Dis 155:667-72

Showing the most recent 10 out of 11 publications