Abstract

The objective is to facilitate research in leprosy by provision of research materials, prepared from purified Mycobacterium Leprae to qualified basic and clinical research scientists. The M. leprae organisms are prepared from tissue taken from infected armadillos. Materials prepared from these tissues include intact [killed] whole M. leprae cells and a variety of sub cellular materials. These include purified antigens, proteins, polysaccharides, lipids, nucleic acids, and other sub cellular materials and fractions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research and Development Contracts (N01)
Project #
N01AI055262-011
Application #
6334063
Study Section
Project Start
1995-06-29
Project End
2002-06-29
Budget Start
2000-06-30
Budget End
2001-06-29
Support Year
Fiscal Year
2000
Total Cost
$426,468
Indirect Cost

  Institution

Name
Colorado State University-Fort Collins
Department
Microbiology/Immun/Virology
Type
Schools of Veterinary Medicine
DUNS #
112617480
City
Fort Collins
State
CO
Country
United States
Zip Code
80523

  Publications

Torrelles, Jordi B; Sieling, Peter A; Zhang, Nannan et al. (2012) Isolation of a distinct Mycobacterium tuberculosis mannose-capped lipoarabinomannan isoform responsible for recognition by CD1b-restricted T cells. Glycobiology 22:1118-27
Martins, Marcia V S B; Guimarães, Marjorie M da S; Spencer, John S et al. (2012) Pathogen-specific epitopes as epidemiological tools for defining the magnitude of Mycobacterium leprae transmission in areas endemic for leprosy. PLoS Negl Trop Dis 6:e1616
Youn, Ju Ho; Myung, Han-Jeong; Liav, Abraham et al. (2004) Production and characterization of peptide mimotopes of phenolic glycolipid-I of Mycobacterium leprae. FEMS Immunol Med Microbiol 41:51-7
Ngamying, Maeya; Sawanpanyalert, Pathom; Butraporn, Raywadee et al. (2003) Effect of vaccination with refined components of the organism on infection of mice with Mycobacterium leprae. Infect Immun 71:1596-8
Spencer, John S; Marques, Maria Angela M; Lima, Monica C B S et al. (2002) Antigenic specificity of the Mycobacterium leprae homologue of ESAT-6. Infect Immun 70:1010-3
Maeda, Yumi; Makino, Masahiko; Crick, Dean C et al. (2002) Novel 33-kilodalton lipoprotein from Mycobacterium leprae. Infect Immun 70:4106-11
Ngamying, M; Varachit, P; Phaknilrat, P et al. (2001) Effects of vaccination with several mycobacterial proteins and lipoproteins on Mycobacterium leprae infection of the mouse. Int J Lepr Other Mycobact Dis 69:43-5
Marques, M A; Mahapatra, S; Sarno, E N et al. (2001) Further biochemical characterization of Mycobacterium leprae laminin-binding proteins. Braz J Med Biol Res 34:463-70
Marques, M A; Ant nio, V L; Sarno, E N et al. (2001) Binding of alpha2-laminins by pathogenic and non-pathogenic mycobacteria and adherence to Schwann cells. J Med Microbiol 50:23-8
Saleh, M T; Fillon, M; Brennan, P J et al. (2001) Identification of putative exported/secreted proteins in prokaryotic proteomes. Gene 269:195-204

Showing the most recent 10 out of 13 publications