Develop or optimize new clinically useful formulations for experimental antiviral drugs or other drugs used to treat AIDS or other infectious diseases. These formulations may demonstrate increased drug or formulation stability, increased targeting to diseased cells/tissues, increased bioavailability, increased acceptance of use, specialized uses and/or new routes of administration. Determine physical/chemical properties (e.g. solubility, dissociation constant, partition coefficient, etc.) of drugs identified for formulation development, and identify potential drug-excipient interactions. Determine drug stability alone and in dosage formulation, and define drug release properties.

Project Start
1995-06-30
Project End
2000-06-29
Budget Start
1995-06-30
Budget End
1996-06-29
Support Year
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Kansas Lawrence
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
072933393
City
Lawrence
State
KS
Country
United States
Zip Code
66045
Haslam, J L; Egodage, K L; Chen, Y et al. (1999) Stability of rifabutin in two extemporaneously compounded oral liquids. Am J Health Syst Pharm 56:333-6