Abstract

This acquisition is for the maintenance of an international bone marrow transplant registry (IBMTR). The purpose of the IBMTR is to pool data acquired from national and international transplant centers and to analyze this data in a disciplined and thoroughly tested manner. To date, a data base of over 3,000 recipients exists with over 1,000 accruing during the past 18 months. The increased frequency of bone marrow transplants supports the need for the IBMTR's continuing acquisition and analysis of the rapidly expanding data base. The data and results acquired through this acquisition shall potentially improve the prognosis for individuals at risk because of congenital or other cause of immunodeficiencies. These results shall assist in the development and production of monoclonal antibody therapy used to abrogate graft versus host disease and provide a more comprehensive data base upon which to design more efficient procedures for allogeneic bone marrow transplantation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research and Development Contracts (N01)
Project #
N01AI062530-000
Application #
3595291
Study Section
Project Start
1986-04-01
Project End
Budget Start
1986-04-01
Budget End
1987-03-31
Support Year
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Medical College of Wisconsin
Department
Type
Schools of Medicine
DUNS #
073134603
City
Milwaukee
State
WI
Country
United States
Zip Code
53226

  Publications

Gluckman, E; Horowitz, M M; Champlin, R E et al. (1992) Bone marrow transplantation for severe aplastic anemia: influence of conditioning and graft-versus-host disease prophylaxis regimens on outcome. Blood 79:269-75
Rimm, A A; Barr, J T; Horowitz, M M et al. (1991) Use of a clinical data registry to evaluate medical technologies. Experience from the International Bone Marrow Transplant Registry. Int J Technol Assess Health Care 7:182-93
Marmont, A M; Horowitz, M M; Gale, R P et al. (1991) T-cell depletion of HLA-identical transplants in leukemia. Blood 78:2120-30
Ash, R C; Horowitz, M M; Gale, R P et al. (1991) Bone marrow transplantation from related donors other than HLA-identical siblings: effect of T cell depletion. Bone Marrow Transplant 7:443-52
Gale, R P; Butturini, A; Horowitz, M M (1991) Does more intensive therapy increase cures in acute leukemia? Semin Hematol 28:93-4
Gale, R P; Butturini, A; Bortin, M M (1991) What does total body irradiation do in bone marrow transplants for leukemia? Int J Radiat Oncol Biol Phys 20:631-4
Keating, A; Horowitz, M M (1991) Evaluating new therapy for acute myeloid leukemia. Semin Hematol 28:70-1
Horowitz, M M; Bortin, M M (1990) Current status of allogeneic bone marrow transplantation. Clin Transpl :41-52
Gale, R P; Horowitz, M M (1990) Graft-versus-leukemia in bone marrow transplantation. The Advisory Committee of the International Bone Marrow Transplant Registry. Bone Marrow Transplant 6 Suppl 1:94-7
Atkinson, K; Horowitz, M M; Gale, R P et al. (1990) Risk factors for chronic graft-versus-host disease after HLA-identical sibling bone marrow transplantation. Blood 75:2459-64

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