Abstract

This project will support a clinical trial utilizing monoclonal antibodies to remove immunocompetent T cells from donor marrow prior to infusion into the recipient in an effort to eliminate or reduce the occurance of graft versus host disease. Monoclonal antibodies will also be used post-transplant, as necessary, to treat graft versus host disease. The result from this study will provide more comprehensive insight into designing efficacious treatment modalities for bone marrow transplant.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research and Development Contracts (N01)
Project #
N01AI062531-001
Application #
3595298
Study Section
Project Start
1986-04-01
Project End
Budget Start
1987-05-19
Budget End
1989-03-31
Support Year
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Soiffer, R J; Murray, C; Mauch, P et al. (1992) Prevention of graft-versus-host disease by selective depletion of CD6-positive T lymphocytes from donor bone marrow. J Clin Oncol 10:1191-200
Soiffer, R J; Mauch, P; Tarbell, N J et al. (1991) Total lymphoid irradiation to prevent graft rejection in recipients of HLA non-identical T cell-depleted allogeneic marrow. Bone Marrow Transplant 7:23-33
Delage, R; Soiffer, R J; Dear, K et al. (1991) Clinical significance of bcr-abl gene rearrangement detected by polymerase chain reaction after allogeneic bone marrow transplantation in chronic myelogenous leukemia. Blood 78:2759-67
Soiffer, R J; Dear, K; Rabinowe, S N et al. (1991) Hepatic dysfunction following T-cell-depleted allogeneic bone marrow transplantation. Transplantation 52:1014-9
Lew, M A; Kehoe, K; Ritz, J et al. (1991) Prophylaxis of bacterial infections with ciprofloxacin in patients undergoing bone marrow transplantation. Transplantation 51:630-6
Klumpp, T R; Caligiuri, M A; Rabinowe, S N et al. (1990) Autoimmune pancytopenia following allogeneic bone marrow transplantation. Bone Marrow Transplant 6:445-7
Soiffer, R J; Bosserman, L; Murray, C et al. (1990) Reconstitution of T-cell function after CD6-depleted allogeneic bone marrow transplantation. Blood 75:2076-84
Bosserman, L D; Murray, C; Takvorian, T et al. (1989) Mechanism of graft failure in HLA-matched and HLA-mismatched bone marrow transplant recipients. Bone Marrow Transplant 4:239-45