Abstract

The objective of this research is to utilize an animal model of influenza virus infection, which has several features similar to the human disease, for evaluating the preclinical potential of candidate antiviral agents. The animal model consists of an infection of laboratory mice which have been used successfully for evaluating influenza virus-inhibitory compounds and biological response modifiers (BRMs) in the now-terminating NIAID Animal Models contract. This model employs several parameters for measuring disease severity. including utilization of pulse oximetry currently widely used in the clinic for monitoring daily blood oxygen saturation. The overall research plan utilizes a blend of virologic expertise with this virus, chemotherapeutic expertise, and immunologic backgrounds well suited to achieve the work required.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research and Development Contracts (N01)
Project #
N01AI065291-009
Application #
6365885
Study Section
Project Start
1995-11-30
Project End
2000-11-30
Budget Start
2000-09-28
Budget End
2001-03-30
Support Year
Fiscal Year
2000
Total Cost
$128,996
Indirect Cost

  Institution

Name
Utah State University
Department
Veterinary Sciences
Type
Schools of Earth Sciences/Natur
DUNS #
City
Logan
State
UT
Country
United States
Zip Code
84322

  Publications

Julander, Justin G; Winger, Quinton A; Olsen, Aaron L et al. (2005) Treatment of West Nile virus-infected mice with reactive immunoglobulin reduces fetal titers and increases dam survival. Antiviral Res 65:79-85
Day, Craig W; Smee, Donald F; Julander, Justin G et al. (2005) Error-prone replication of West Nile virus caused by ribavirin. Antiviral Res 67:38-45
Smee, Donald F; Wandersee, Miles K; Wong, Min-Hui et al. (2004) Treatment of mannan-enhanced influenza B virus infections in mice with oseltamivir, ribavirin and viramidine. Antivir Chem Chemother 15:261-8
Smee, Donald F; Wong, Min-Hui; Bailey, Kevin W et al. (2004) Effects of four antiviral substances on lethal vaccinia virus (IHD strain) respiratory infections in mice. Int J Antimicrob Agents 23:430-7
Morrey, John D; Day, Craig W; Julander, Justin G et al. (2004) Modeling hamsters for evaluating West Nile virus therapies. Antiviral Res 63:41-50
Morrey, John D; Day, Craig W; Julander, Justin G et al. (2004) Effect of interferon-alpha and interferon-inducers on West Nile virus in mouse and hamster animal models. Antivir Chem Chemother 15:101-9
Smee, Donald F; Bailey, Kevin W; Sidwell, Robert W (2003) Comparative effects of cidofovir and cyclic HPMPC on lethal cowpox and vaccinia virus respiratory infections in mice. Chemotherapy 49:126-31
Shi, Limin; Fatemi, S Hossein; Sidwell, Robert W et al. (2003) Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring. J Neurosci 23:297-302
Smee, Donald F; Bailey, Kevin W; Sidwell, Robert W (2002) Treatment of lethal cowpox virus respiratory infections in mice with 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine and its orally active diacetate ester prodrug. Antiviral Res 54:113-20
Smee, Donald F; Bailey, Kevin W; Morrison, Ann C et al. (2002) Combination treatment of influenza A virus infections in cell culture and in mice with the cyclopentane neuraminidase inhibitor RWJ-270201 and ribavirin. Chemotherapy 48:88-93

Showing the most recent 10 out of 30 publications