This contract will evaluate substances in cotton rats for their clinical therapeutic or prophylactic potential to safely treat or prevent paramyxovirus (respiratory syncytial virus, parainfluenza virus type 3, and measles virus)-induced infectious diseases of humans. In addition, the models will be used to study the disease pathogenesis of these viruses and host responses to infections caused by these viruses. When appropriate, these models will also be used for a limited amount of vaccine evaluation and pharmacokinetic studies.

Project Start
1995-12-02
Project End
2000-11-30
Budget Start
1997-11-21
Budget End
1998-11-30
Support Year
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
Wyde, Philip R; Chetty, Srikrishna N; Jewell, Alan M et al. (2005) Development of a cotton rat-human metapneumovirus (hMPV) model for identifying and evaluating potential hMPV antivirals and vaccines. Antiviral Res 66:57-66
Wyde, Philip R; Moylett, Edina H; Chetty, Srikrishna N et al. (2004) Comparison of the inhibition of human metapneumovirus and respiratory syncytial virus by NMSO3 in tissue culture assays. Antiviral Res 63:51-9
Wyde, Philip R; Chetty, Srikrishna N; Jewell, Alan M et al. (2003) Comparison of the inhibition of human metapneumovirus and respiratory syncytial virus by ribavirin and immune serum globulin in vitro. Antiviral Res 60:51-9
Wyde, P R; Moore-Poveda, D K; De Clercq, E et al. (2000) Use of cotton rats to evaluate the efficacy of antivirals in treatment of measles virus infections. Antimicrob Agents Chemother 44:1146-52
Wyde, P R; Stittelaar, K J; Osterhaus, A D et al. (2000) Use of cotton rats for preclinical evaluation of measles vaccines. Vaccine 19:42-53
Wyde, P R; Moore-Poveda, D K; Daley, N J et al. (1999) Replication of clinical measles virus strains in hispid cotton rats. Proc Soc Exp Biol Med 221:53-62
Wyde, P R (1998) Respiratory syncytial virus (RSV) disease and prospects for its control. Antiviral Res 39:63-79
Wyde, P R; Moore-Poveda, D K; O'Hara, B et al. (1998) CL387626 exhibits marked and unusual antiviral activity against respiratory syncytial virus in tissue culture and in cotton rats. Antiviral Res 38:31-42
Faith, R E; Montgomery, C A; Durfee, W J et al. (1997) The cotton rat in biomedical research. Lab Anim Sci 47:337-45