This contract is designed to evaluate experimental HIV vaccine strategies in non-human primates before these vaccines proceed into clinical trials. Vaccines will be tested for safety and immunogenicity. Challenge studies using Simian immunodeficiency Virus (SIV) or chimeric HIV/SIV (SHIV) viruses will also be performed. Vaccine strategies investigated will include nucleic acid vaccines, recombinant proteins, whole-killed and attenuated viral vaccines as well as immunologic adjuvants and delivery vehicles. The contractor must acquire, house, and monitor health and infection status on at least 50 non-human primates the first year and 25 additional animal in the subsequent years of the contract Biosafety facilities for housing and laboratory work for the animals must be provided. The contractor is also responsible for the development of protocols for each vaccine study and performing immunIzations, and collection of blood, cells and tissue as required. Immunologic and virologic assays will also be performed by the contractor. Specimens will be stored as required and specimens will be shipped as required by the program Project Officer. The contractor will supply written and electronically transmitted reports as specified. The SVEUs are a critical component in HIV vaccine research and development supported by the Division of AIDS.

Project Start
1996-04-01
Project End
2001-03-31
Budget Start
1996-12-19
Budget End
1998-03-31
Support Year
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Tulane University
Department
Type
Other Domestic Higher Education
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70118
Fuller, Deborah Heydenburg; Rajakumar, Premeela A; Wu, Mary S et al. (2006) DNA immunization in combination with effective antiretroviral drug therapy controls viral rebound and prevents simian AIDS after treatment is discontinued. Virology 348:200-15
Ling, B; Veazey, R S; Penedo, C et al. (2002) Longitudinal follow up of SIVmac pathogenesis in rhesus macaques of Chinese origin: emergence of B cell lymphoma. J Med Primatol 31:154-63
Croix, Denise A; Board, Kathryn; Capuano 3rd, Saverio et al. (2002) Alterations in T lymphocyte profiles of bronchoalveolar lavage fluid from SIV- and Pneumocystis carinii-coinfected rhesus macaques. AIDS Res Hum Retroviruses 18:391-401
Fuller, Deborah Heydenburg; Rajakumar, Premeela A; Wilson, Lawrence A et al. (2002) Induction of mucosal protection against primary, heterologous simian immunodeficiency virus by a DNA vaccine. J Virol 76:3309-17
Trichel, A M; Rajakumar, P A; Murphey-Corb, M (2002) Species-specific variation in SIV disease progression between Chinese and Indian subspecies of rhesus macaque. J Med Primatol 31:171-8
Newman, G W; Adams, D L; Maslow, J N et al. (1999) Differential tumor necrosis factor alpha production in simian immunodeficiency virus-infected rhesus macaques coinfected with Mycobacterium avium. Clin Infect Dis 28:514-9