Abstract

This contract is designed to evaluate experimental HIV vaccine strategies in non-human primates before these vaccines would proceed into clinical trials. Vaccines will be tested for safety and immunogenicity. Challenge studies using Simian Immunodeficiency Virus (SIV) or chimeric HIV/(SIV (SHIV) viruses will also be performed. Vaccine strategies investigated will include nucleic acid vaccines, recombinant proteins, whole-killed and attenuated viral vaccines as well as immunologic adjuvants and antigen delivery systems.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research and Development Contracts (N01)
Project #
N01AI065314-003
Application #
6158934
Study Section
Project Start
1996-09-30
Project End
2001-09-29
Budget Start
1999-09-10
Budget End
2001-09-29
Support Year
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Advanced Bioscience Laboratories, Inc.
Department
Type
DUNS #
City
Kensington
State
MD
Country
United States
Zip Code
20895

  Publications

Pal, Ranajit; Taylor, Brian; Foulke, J Scott et al. (2003) Characterization of a simian human immunodeficiency virus encoding the envelope gene from the CCR5-tropic HIV-1 Ba-L. J Acquir Immune Defic Syndr 33:300-7
Fouts, Timothy; Godfrey, Karla; Bobb, Kathryn et al. (2002) Crosslinked HIV-1 envelope-CD4 receptor complexes elicit broadly cross-reactive neutralizing antibodies in rhesus macaques. Proc Natl Acad Sci U S A 99:11842-7