Abstract

The contractor serves a general Vaccine Evaluation Unit for the Development and Applications Branch, MIDP, NIAID. Phase 1 and 2 clinical studies will be performed in adult, adolescent and pediatric groups consisting of normal and """"""""at risk"""""""" individuals. Correlates of immunity for various vaccine candidates will be studied. In addition to clinical trials, limited epidemiologic surveillance studies will be performed to determine the presence of infectious disease agents for which prevention studies are being designed. Examples of vaccines to be studied are: Haemophilus influenzae type b conjugates, group B meningococcal vaccine, hepatitis A and B vaccines, rotavirus vaccines, and new acellular pertussis vaccines. There is a possibility that vaccine candidates for HIV will undergo early phase 1 trials at this and other Vaccine Evaluation Units.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research and Development Contracts (N01)
Project #
N01AI072629-004
Application #
3595970
Study Section
Project Start
1987-01-20
Project End
1991-12-19
Budget Start
1987-11-20
Budget End
1988-12-19
Support Year
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Keitel, Wendy A (2002) Repeated immunization of children with inactivated and live attenuated influenza virus vaccines: safety, immunogenicity, and protective efficacy. Semin Pediatr Infect Dis 13:112-9
Rennels, Margaret B; Deloria, Maria A; Pichichero, Michael E et al. (2002) Lack of consistent relationship between quantity of aluminum in diphtheria-tetanus-acellular pertussis vaccines and rates of extensive swelling reactions. Vaccine 20 Suppl 3:S44-7
Rennels, M B; Englund, J A; Bernstein, D I et al. (2000) Diminution of the anti-polyribosylribitol phosphate response to a combined diphtheria-tetanus-acellular pertussis/Haemophilus influenzae type b vaccine by concurrent inactivated poliovirus vaccination. Pediatr Infect Dis J 19:417-23
Pichichero, M E; Christy, C; Decker, M D et al. (1995) Defining the key parameters for comparing reactions among acellular and whole-cell pertussis vaccines. Pediatrics 96:588-92
Meade, B D; Deforest, A; Edwards, K M et al. (1995) Description and evaluation of serologic assays used in a multicenter trial of acellular pertussis vaccines. Pediatrics 96:570-5
Anderson, E L; Decker, M D; Englund, J A et al. (1995) Interchangeability of conjugated Haemophilus influenzae type b vaccines in infants. JAMA 273:849-53
Deloria, M A; Blackwelder, W C; Decker, M D et al. (1995) Association of reactions after consecutive acellular or whole-cell pertussis vaccine immunizations. Pediatrics 96:592-4
Meade, B D; Lynn, F; Reed, G F et al. (1995) Relationships between functional assays and enzyme immunoassays as measurements of responses to acellular and whole-cell pertussis vaccines. Pediatrics 96:595-600
Edwards, K M; Meade, B D; Decker, M D et al. (1995) Comparison of 13 acellular pertussis vaccines: overview and serologic response. Pediatrics 96:548-57
Decker, M D; Edwards, K M; Steinhoff, M C et al. (1995) Comparison of 13 acellular pertussis vaccines: adverse reactions. Pediatrics 96:557-66

Showing the most recent 10 out of 19 publications