Abstract

The overall objective of this Sexually Transmitted Diseases Clinical Trial Unit (STD CTU) contract is to conduct clinical trials to test safety and efficacy of biomedical and behavioral interventions aimed at prevention and control of sexually transmitted diseases (STDs). Diseases or pathogens which may be studied under this contract include, but are not limited to: chlamydial infection; gonorrhea; syphilis, chancroid; human papillomavirus (HPV) infection; genital herpes (herpes simplex virus 1 & 2 infections), human herpes virus 8 (kaposi's sarcoma virus) and human immunodeficiency virus (HIV) infection as it is associated with other STDs (both in terms of increased transmission rates of HIV and alteration of the natural history of STDs). The syndromes to be studied under this contract may include, but are not limited to: pelvic inflammatory disease (and sequelae - infertility, ectopic pregnancy and chronic pelvic pain); adverse outcomes of pregnancy; and cervical cancer as well as other genital cancers associated with HPV infection. The prevention and control strategies to be studied may encompass primary, secondary and tertiary prevention. The interventions to be studied may include, but are not limited to: topical microbicides, vaccines, diagnostics tests, screening tests, therapeutics and behavior change.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research and Development Contracts (N01)
Project #
N01AI075329-004
Application #
2880127
Study Section
Project Start
1997-09-30
Project End
2002-09-29
Budget Start
1998-09-30
Budget End
2001-06-06
Support Year
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Seña, Arlene C; Wolff, Mark; Behets, Frieda et al. (2017) Rate of Decline in Nontreponemal Antibody Titers and Seroreversion After Treatment of Early Syphilis. Sex Transm Dis 44:6-10
Holman, Katherine M; Wolff, Mark; Seña, Arlene C et al. (2012) Rapid plasma reagin titer variation in the 2 weeks after syphilis therapy. Sex Transm Dis 39:645-7
Marra, Christina M; Sahi, Sharon K; Tantalo, Lauren C et al. (2010) Enhanced molecular typing of treponema pallidum: geographical distribution of strain types and association with neurosyphilis. J Infect Dis 202:1380-8
Gallo, Maria F; Steiner, Markus J; Hobbs, Marcia M et al. (2010) Predictors of unprotected sex among female sex workers in Madagascar: comparing semen biomarkers and self-reported data. AIDS Behav 14:1279-86
Van Damme, Kathleen; Behets, Frieda; Ravelomanana, Noro et al. (2009) Evaluation of azithromycin resistance in Treponema pallidum specimens from Madagascar. Sex Transm Dis 36:775-6
Ondondo, Beatrice O; Brunham, Robert C; Harrison, William G et al. (2009) Frequency and magnitude of Chlamydia trachomatis elementary body- and heat shock protein 60-stimulated interferon gamma responses in peripheral blood mononuclear cells and endometrial biopsy samples from women with high exposure to infection. J Infect Dis 199:1771-9
Torok, Michelle R; Miller, William C; Hobbs, Marcia M et al. (2009) The association between oral contraceptives, depot-medroxyprogesterone acetate, and trichomoniasis. Sex Transm Dis 36:336-40
Gallo, M F; Behets, F M; Steiner, M J et al. (2007) Validity of self-reported 'safe sex'among female sex workers in Mombasa, Kenya--PSA analysis. Int J STD AIDS 18:33-8
Cohen, Myron S (2006) Thomas Parran Award Lecture: transmission and prevention of transmission of HIV-1. Sex Transm Dis 33:338-41
Gallo, Maria F; Behets, Frieda M; Steiner, Markus J et al. (2006) Prostate-specific antigen to ascertain reliability of self-reported coital exposure to semen. Sex Transm Dis 33:476-9

Showing the most recent 10 out of 24 publications