This contract is for the continued support of a clinical trial to investigate the efficacy of monoclonal antibodies in preventing kidney graft rejection. The contractor will enroll at least fifty patients into a randomized trial in which, upon transplant, the patient will receive either conventional immunosuppression or a combination of conventional therapy plus monoclonal antibody. The patients will be followed and data collected on various parameters which would show differences in the effectiveness of the two treatment protocols in preventing rejection.

Project Start
1988-07-01
Project End
1992-06-30
Budget Start
1991-06-25
Budget End
1992-06-30
Support Year
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Kirkman, R L; Shapiro, M E; Carpenter, C B et al. (1991) A randomized prospective trial of anti-Tac monoclonal antibody in human renal transplantation. Transplantation 51:107-13
Ramos, E L; Leggat, J E; Milford, E L et al. (1989) In vivo anti-interleukin-2 receptor (anti-Tac) therapy is immunosuppressive, but not tolerogenic. Trans Assoc Am Physicians 102:231-9