This contract is for the development of monoclonal antibodies to polymorphic tissue specific antigens which may play an important role in graft rejection. The contractor will use classical immunization, fusion and screening techniques to derive and characterize monoclonal antibodies to tissues from heart and other organs. In addition the contractor will use monomorphic monoclonal antibodies developed under a prior contract to precipitate antigens from crude whole organ preparations and use this precipitate to immunize mice in the hope of producing monoclonal antibodies to polymorphic antigens which are transplant relevant.

Project Start
1988-03-01
Project End
1992-02-29
Budget Start
1988-03-01
Budget End
1989-02-28
Support Year
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Type
Schools of Medicine
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506