Abstract

This contract will support investigation of the effect, in vivo, of recombinant lymphokines on bone marrow transplantation in a murine model. In addition, the efficacy of monoclonal antibodies in lysing host cells which may be involved in graft rejection will be examined. These studies are designed to test new methods for optimizing conditioning regimens to promote marrow engraftment.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research and Development Contracts (N01)
Project #
N01AI085002-002
Application #
3597245
Study Section
Project Start
1988-09-30
Project End
1993-09-29
Budget Start
1990-05-17
Budget End
1991-09-29
Support Year
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Davies, S M; Wagner, J E; Shu, X O et al. (1997) Unrelated donor bone marrow transplantation for children with acute leukemia. J Clin Oncol 15:557-65
Davies, S M; Khan, S; Wagner, J E et al. (1996) Unrelated donor bone marrow transplantation for Fanconi anemia. Bone Marrow Transplant 17:43-7
Pawlowska, A B; Davies, S M; Orchard, P J et al. (1996) Unrelated donor bone marrow transplantation for acute leukemia in patients with Down's syndrome. Bone Marrow Transplant 18:453-5
Davies, S M; Szabo, E; Wagner, J E et al. (1996) Idiopathic hyperammonemia: a frequently lethal complication of bone marrow transplantation. Bone Marrow Transplant 17:1119-25
Orchard, P J; McIvor, R S; Singh, H A et al. (1995) GM-CSF-induced internal autocrine proliferation occurs in a compartment outside of the endoplasmic reticulum. Exp Hematol 23:573-82
Katsanis, E; Blazar, B R; Bausero, M A et al. (1994) Retroperitoneal inoculation of murine neuroblastoma results in a reliable model for evaluation of the antitumor immune response. J Pediatr Surg 29:538-42
Hings, I M; Severson, R; Filipovich, A H et al. (1994) Treatment of moderate and severe acute GVHD after allogeneic bone marrow transplantation. Transplantation 58:437-42
Lane, P H; Mauer, S M; Blazar, B R et al. (1994) Outcome of dialysis for acute renal failure in pediatric bone marrow transplant patients. Bone Marrow Transplant 13:613-7
Katsanis, E; Bausero, M A; Xu, H et al. (1994) Transfection of the mouse ICAM-1 gene into murine neuroblastoma enhances susceptibility to lysis, reduces in vivo tumorigenicity and decreases ICAM-2-dependent killing. Cancer Immunol Immunother 38:135-41
Davies, S M; Ramsay, N K; Haake, R J et al. (1994) Comparison of engraftment in recipients of matched sibling of unrelated donor marrow allografts. Bone Marrow Transplant 13:51-7

Showing the most recent 10 out of 21 publications