Project Start
1998-09-30
Project End
2003-09-29
Budget Start
2000-09-21
Budget End
2002-08-30
Support Year
Fiscal Year
2000
Total Cost
$621,856
Indirect Cost
Name
University of Alabama Birmingham
Department
Pediatrics
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Choo, Hyunah; Beadle, James R; Kern, Earl R et al. (2007) Antiviral activities of novel 5-phosphono-pent-2-en-1-yl nucleosides and their alkoxyalkyl phosphonoesters. Antimicrob Agents Chemother 51:611-5
Zhou, Shaoman; Zemlicka, Jiri; Kern, Earl R et al. (2007) Fluoroanalogues of anti-cytomegalovirus agent cyclopropavir: synthesis and antiviral activity of (E)- and (Z)-9-{[2,2-bis(hydroxymethyl)-3-fluorocyclopropylidene]methyl}-adenines and guanines. Nucleosides Nucleotides Nucleic Acids 26:231-43
Beadle, James R; Wan, William B; Ciesla, Stephanie L et al. (2006) Synthesis and antiviral evaluation of alkoxyalkyl derivatives of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine against cytomegalovirus and orthopoxviruses. J Med Chem 49:2010-5
Ruiz, Jacqueline C; Aldern, Kathy A; Beadle, James R et al. (2006) Synthesis and antiviral evaluation of alkoxyalkyl esters of phosphonopropoxymethyl-guanine and phosphonopropoxymethyl-diaminopurine. Antivir Chem Chemother 17:89-95
Zhou, Shaoman; Kern, Earl R; Gullen, Elizabeth et al. (2006) 9-{[3-fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. Synthesis and antiviral activity of all stereoisomers1. J Med Chem 49:6120-8
Kriesel, John D; Spruance, Spotswood L; Prichard, Mark et al. (2005) Recurrent antiviral-resistant genital herpes in an immunocompetent patient. J Infect Dis 192:156-61
Yan, Zhaohua; Kern, Earl R; Gullen, Elizabeth et al. (2005) Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity. J Med Chem 48:91-9
Patel, Kunal; Trivedi, Shrija; Luo, Shuanghui et al. (2005) Synthesis, physicochemical properties and antiviral activities of ester prodrugs of ganciclovir. Int J Pharm 305:75-89
Kern, Earl R; Kushner, Nicole L; Hartline, Caroll B et al. (2005) In vitro activity and mechanism of action of methylenecyclopropane analogs of nucleosides against herpesvirus replication. Antimicrob Agents Chemother 49:1039-45
Hartline, Caroll B; Gustin, Kortney M; Wan, William B et al. (2005) Ether lipid-ester prodrugs of acyclic nucleoside phosphonates: activity against adenovirus replication in vitro. J Infect Dis 191:396-9

Showing the most recent 10 out of 34 publications