This contract provides the interface with academic establishments and the private sector for evaluation of new classes of compounds for activity against M. tuberculosis. This acquisition component actively canvases medicinal chemists and pursues chemicals and natural products described in the academic literature and in compounds identified via pharmaceutical company repositories. The contract serves as the central storage repository of agents prior to testing. All compounds are tested under a confidentiality agreement and new compounds will be registered with the existing chemical structure database to avoid duplicative testing. The emphasis for exploration in the current contract will be for compounds to kill quiescent or dormant tubercle bacilli present in the latent phase of disease. The contractor is responsible for supplying biological data to the suppliers and for serving as a central contact for further drug development interactions.
| Mathew, Bini; Hobrath, Judith Varady; Ross, Larry et al. (2016) Screening and Development of New Inhibitors of FtsZ from M. Tuberculosis. PLoS One 11:e0164100 |
| Simithy, Johayra; Reeve, Nathaniel; Hobrath, Judith V et al. (2014) Identification of shikimate kinase inhibitors among anti-Mycobacterium tuberculosis compounds by LC-MS. Tuberculosis (Edinb) 94:152-8 |
| Pathak, Ashish K; Pathak, Vibha; Seitz, Lainne E et al. (2013) 6-Oxo and 6-thio purine analogs as antimycobacterial agents. Bioorg Med Chem 21:1685-95 |
| Wilson, Regina; Kumar, Pradeep; Parashar, Vijay et al. (2013) Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis. Nat Chem Biol 9:499-506 |
| Reynolds, Robert C; Ananthan, Subramaniam; Faaleolea, Ellen et al. (2012) High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv. Tuberculosis (Edinb) 92:72-83 |
| Vicente, Esther; Villar, Raquel; Perez-Silanes, Silvia et al. (2011) Quinoxaline 1,4-di-N-oxide and the potential for treating tuberculosis. Infect Disord Drug Targets 11:196-204 |
| Macaev, Fliur; Ribkovskaia, Zinaida; Pogrebnoi, Serghei et al. (2011) The structure-antituberculosis activity relationships study in a series of 5-aryl-2-thio-1,3,4-oxadiazole derivatives. Bioorg Med Chem 19:6792-807 |
| Hoff, Donald R; Ryan, Gavin J; Driver, Emily R et al. (2011) Location of intra- and extracellular M. tuberculosis populations in lungs of mice and guinea pigs during disease progression and after drug treatment. PLoS One 6:e17550 |
| Imramovsky, Ales; Vinsova, Jarmila; Ferriz, Juana Monreal et al. (2009) Salicylanilide esters of N-protected amino acids as novel antimicrobial agents. Bioorg Med Chem Lett 19:348-51 |
| Ananthan, Subramaniam; Faaleolea, Ellen R; Goldman, Robert C et al. (2009) High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv. Tuberculosis (Edinb) 89:334-53 |
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