Project Start
1999-09-30
Project End
2006-09-29
Budget Start
1999-09-30
Budget End
2000-09-29
Support Year
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Colorado State University-Fort Collins
Department
Microbiology/Immun/Virology
Type
Schools of Veterinary Medicine
DUNS #
112617480
City
Fort Collins
State
CO
Country
United States
Zip Code
80523
Palencia, Andrés; Li, Xianfeng; Bu, Wei et al. (2016) Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase. Antimicrob Agents Chemother 60:6271-80
Usha, Veeraraghavan; Hobrath, Judith V; Gurcha, Sudagar S et al. (2012) Identification of novel Mt-Guab2 inhibitor series active against M. tuberculosis. PLoS One 7:e33886
Gonzalez-Juarrero, Mercedes; Woolhiser, Lisa K; Brooks, Elizabeth et al. (2012) Mouse model for efficacy testing of antituberculosis agents via intrapulmonary delivery. Antimicrob Agents Chemother 56:3957-9
Driver, Emily R; Ryan, Gavin J; Hoff, Donald R et al. (2012) Evaluation of a mouse model of necrotic granuloma formation using C3HeB/FeJ mice for testing of drugs against Mycobacterium tuberculosis. Antimicrob Agents Chemother 56:3181-95
Vicente, Esther; Villar, Raquel; Perez-Silanes, Silvia et al. (2011) Quinoxaline 1,4-di-N-oxide and the potential for treating tuberculosis. Infect Disord Drug Targets 11:196-204
Hoff, Donald R; Ryan, Gavin J; Driver, Emily R et al. (2011) Location of intra- and extracellular M. tuberculosis populations in lungs of mice and guinea pigs during disease progression and after drug treatment. PLoS One 6:e17550
Ryan, Gavin J; Hoff, Donald R; Driver, Emily R et al. (2010) Multiple M. tuberculosis phenotypes in mouse and guinea pig lung tissue revealed by a dual-staining approach. PLoS One 5:e11108
Woolhiser, Lisa K; Hoff, Donald R; Marietta, Karen S et al. (2009) Testing of experimental compounds in a relapse model of tuberculosis using granulocyte-macrophage colony-stimulating factor gene-disrupted mice. Antimicrob Agents Chemother 53:306-8
Hoff, Donald R; Caraway, Megan L; Brooks, Elizabeth J et al. (2008) Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis. Antimicrob Agents Chemother 52:4137-40
Lenaerts, Anne J; Degroote, Mary Ann; Orme, Ian M (2008) Preclinical testing of new drugs for tuberculosis: current challenges. Trends Microbiol 16:48-54

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