The specific objectives of this contract are: 1) to define the acute toxicities of new anticancer agents in patients with advanced cancer; 2) to redefine the acute toxicities and pharmacokinetics of anticancer administered in combination with agents to modulate toxicity or antitumor effect; 3) to provide information on the pharmacokinetic characteristics (absorption, distribution, metabolism and elimination) and pharmacodynamics of selected antitumor agents; and 4) to determine a treatment regimen suitable for evaluation of antitumor activity in Phase II trials.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Treatment (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CM007305-004
Application #
3607890
Study Section
Project Start
1990-06-01
Project End
1995-05-31
Budget Start
1992-08-24
Budget End
1993-02-20
Support Year
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Texas Health Science Center San Antonio
Department
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Huhn, R D; Yurkow, E J; Kuhn, J G et al. (1995) Pharmacodynamics of daily subcutaneous recombinant human interleukin-3 in normal volunteers. Clin Pharmacol Ther 57:32-41