Synthesis of Radiosensitizing Agents

Wilson, William R.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: Division of Cancer Treatment (NCI)
• Type: Research and Development Contracts (N01)
• Project #: N01CM007321-002
• Application #: 3607994
• Project Start: 1990-09-30
• Project End: 1993-09-29
• Budget Start: 1991-02-14
• Budget End: 1991-09-29
• Fiscal Year: 1991

Institution

• Name: University of Auckland
• City: Auckland
• Country: New Zealand
• Zip Code: 1010

Publications

Denny, W A; Wilson, W R; Hay, M P (1996) Recent developments in the design of bioreductive drugs. Br J Cancer Suppl 27:S32-8

Moselen, J W; Hay, M P; Denny, W A et al. (1995) N-[2-(2-methyl-5-nitroimidazolyl)ethyl]-4-(2-nitroimidazolyl)butanamide (NSC 639862), a bisnitroimidazole with enhanced selectivity as a bioreductive drug. Cancer Res 55:574-80

Denny, W A; Atwell, G J; Roberts, P B et al. (1992) Hypoxia-selective antitumor agents. 6. 4-(Alkylamino)nitroquinolines: a new class of hypoxia-selective cytotoxins. J Med Chem 35:4832-41

Wilson, W R; Siim, B G; Denny, W A et al. (1992) 5-Nitro-4-(N,N-dimethylaminopropylamino)quinoline (5-nitraquine), a new DNA-affinic hypoxic cell radiosensitizer and bioreductive agent: comparison with nitracrine. Radiat Res 131:257-65