The objectives of this project are to design and synthesize the following: (a) Congeners of lead compounds having confirmed activity, to enhance activity or potency; (b) Prodrugs with structural modifications that may provide altered pharmacokinetics, altered drug transport, improved bio-availability through increased water solubility, or increased chemical stability; (c) Other altered structures that possess elements of both congener and prodrug. Modifications of a lead may also include partial structures; and (d) Compounds related to natural products, e.g., alkaloids, heterocycles, nucleosides, peptides, etc. Active leads may also include metal complexes.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Treatment (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CM017513-000
Application #
3609227
Study Section
Project Start
1991-06-30
Project End
1994-06-29
Budget Start
1991-06-30
Budget End
1992-06-29
Support Year
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Purdue University North Central Campus
Department
Type
Schools of Nursing
DUNS #
City
Westville
State
IN
Country
United States
Zip Code
46391