Abstract

The specific objective of this contract will be to provide the Investigational Drug Branch (IDB), CTEP, DCT, NCI, with Phase I clinical evaluations of investigational new drugs which are developed through the DCT Linear Array and are sponsored to the Food and Drug Administration (FDA) under an IND held by DCT. The objective of Phase I studies is to provide the parameters and characteristics of drug toxicity, the maximally tolerated dose, and a recommended Phase II dose.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Treatment (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CM027542-006
Application #
3610110
Study Section
Project Start
1982-04-01
Project End
Budget Start
1985-06-01
Budget End
1985-07-31
Support Year
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Texas Health Science Center San Antonio
Department
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229

  Publications

Weiss, G R; Kuhn, J G; Rizzo, J et al. (1995) A phase I and pharmacokinetics study of 2-chlorodeoxyadenosine in patients with solid tumors. Cancer Chemother Pharmacol 35:397-402
Ravdin, P M; Havlin, K A; Marshall, M V et al. (1991) A phase I clinical and pharmacokinetic trial of hepsulfam. Cancer Res 51:6268-72
Slichenmyer, W J; Von Hoff, D D (1991) Taxol: a new and effective anti-cancer drug. Anticancer Drugs 2:519-30
Kuhn, J G; Von Hoff, D D; Hersh, M et al. (1989) Phase I trial of echinomycin (NSC 526417), a bifunctional intercalating agent, administered by 24-hour continuous infusion. Eur J Cancer Clin Oncol 25:797-803
Hersh, M R; Kuhn, J G; Phillips, J L et al. (1986) Pharmacokinetic study of fludarabine phosphate (NSC 312887). Cancer Chemother Pharmacol 17:277-80
Hutton, J J; Von Hoff, D D (1986) Cytotoxicity of 2-chlorodeoxyadenosine in a human tumor colony-forming assay. Cancer Drug Deliv 3:115-22
Hersh, M R; Linn, W; Kuhn, J G et al. (1986) Electrocardiographic monitoring of patients receiving phase I cancer chemotherapy. Cancer Treat Rep 70:349-52
Dorr, F A; Von Hoff, D D; Kuhn, J G et al. (1986) Phase I clinical investigation of 7-con-O-methylnogaril, a new anthracycline antibiotic. Cancer Res 46:2562-5
Melink, T J; Von Hoff, D D; Kuhn, J G et al. (1985) Phase I evaluation and pharmacokinetics of tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide, NSC 286193). Cancer Res 45:2859-65
Weiss, G R; Hersh, M; Kuhn, J G et al. (1985) A phase I and pharmacokinetic comparison of hepatic arterial and peripheral vein infusions of bisantrene for liver cancer. Cancer Chemother Pharmacol 15:144-8