Agency
National Institute of Health (NIH)
Institute
Division of Cancer Treatment (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CM047580-004
Application #
3611903
Study Section
Project Start
1984-02-16
Project End
1987-02-15
Budget Start
1985-12-10
Budget End
1986-02-15
Support Year
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Southern Research Institute
Department
Type
DUNS #
006900526
City
Birmingham
State
AL
Country
United States
Zip Code
35205
Harrison Jr, S D; Plowman, J; Dykes, D J et al. (1990) Schedule dependence, activity against natural metastases, and cross-resistance of pyrazine diazohydroxide (sodium salt, NSC 361456) in preclinical models in vivo. Cancer Chemother Pharmacol 25:425-9
Dykes, D J; Waud, W R; Harrison Jr, S D et al. (1989) Antitumor activity of 2-chloroethyl (methylsulfonyl)methanesulfonate (clomesone, NSC 33847) against selected tumor systems in mice. Cancer Res 49:1182-6
Plowman, J; Paull, K D; Atassi, G et al. (1988) Preclinical antitumor activity of batracylin (NSC 320846). Invest New Drugs 6:147-53
Plowman, J; Harrison Jr, S D; Trader, M W et al. (1987) Preclinical antitumor activity and pharmacological properties of deoxyspergualin. Cancer Res 47:685-9
Wilkoff, L J; Dulmadge, E A; Trader, M W et al. (1987) Evaluation of trans-tetrachloro-1,2-diaminocyclohexane platinum (IV) in murine leukemia L1210 resistant and sensitive to cis-diamminedichloroplatinum (II). Cancer Chemother Pharmacol 20:96-100
Harrison Jr, S D; Brockman, R W; Trader, M W et al. (1987) Cross-resistance of drug-resistant murine leukemias to deoxyspergualin (NSC 356894) in vivo. Invest New Drugs 5:345-51
Griswold Jr, D P; Trader, M W; Frei 3rd, E et al. (1987) Response of drug-sensitive and -resistant L1210 leukemias to high-dose chemotherapy. Cancer Res 47:2323-7
Shoemaker, R; Wolpert-DeFilippes, M; Plowman, J et al. (1986) Pleiotropic resistance and drug development. Prog Clin Biol Res 223:143-9
Wilkoff, L J; Dulmadge, E A (1986) Sensitivity of proliferating cultured murine pancreatic tumor cells to selected antitumor agents. J Natl Cancer Inst 77:1163-9
Harrison Jr, S D; O'Dwyer, P J; Trader, M W (1986) Therapeutic synergism of tiazofurin and selected antitumor drugs against sensitive and resistant P388 leukemia in mice. Cancer Res 46:3396-400

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