Agency
National Institute of Health (NIH)
Institute
Division of Cancer Treatment (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CM047593-002
Application #
3611962
Study Section
Project Start
1984-06-30
Project End
1987-06-29
Budget Start
1987-01-19
Budget End
1986-06-29
Support Year
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Institute of Microbial Chemistry
Department
Type
DUNS #
City
Tokyo
State
Country
Japan
Zip Code
Kunimoto, S; Takahashi, Y; Uchida, T et al. (1988) Strong binding of ditrisarubicin B to DNA. J Antibiot (Tokyo) 41:655-9
Imoto, M; Umezawa, K; Sawa, T et al. (1987) In situ inhibition of tyrosine protein kinase by erbstatin. Biochem Int 15:989-95
Kunimoto, S; Xu, C Z; Naganawa, H et al. (1987) Reversal of resistance by N-acetyltyramine or N-acetyl-2-phenylethylamine in doxorubicin-resistant leukemia P388 cells. J Antibiot (Tokyo) 40:1651-2
Ishizuka, M; Masuda, T; Mizutani, S et al. (1987) Antitumor cells found in tumor-bearing mice given ubenimex. J Antibiot (Tokyo) 40:697-701
Umezawa, H; Imoto, M; Sawa, T et al. (1986) Studies on a new epidermal growth factor-receptor kinase inhibitor, erbstatin, produced by MH435-hF3. J Antibiot (Tokyo) 39:170-3
Saito, H; Yoshikawa, H; Nishimura, Y et al. (1986) Studies on lignan lactone antitumor agents. I. Synthesis of aminoglycosidic lignan variants related to podophyllotoxin. Chem Pharm Bull (Tokyo) 34:3733-40
Saito, H; Yoshikawa, H; Nishimura, Y et al. (1986) Studies on lignan lactone antitumor agents. II. Synthesis of N-alkylamino- and 2,6-dideoxy-2-aminoglycoside lignan variants related to podophyllotoxin. Chem Pharm Bull (Tokyo) 34:3741-6
Ishizuka, M; Masuda, T; Mizutani, S et al. (1986) Induction of antitumor resistance to mouse leukemia L1210 by spergualins. J Antibiot (Tokyo) 39:1736-43
Uehara, Y; Hori, M; Takeuchi, T et al. (1986) Phenotypic change from transformed to normal induced by benzoquinonoid ansamycins accompanies inactivation of p60src in rat kidney cells infected with Rous sarcoma virus. Mol Cell Biol 6:2198-206
Yamato, M; Iinuma, H; Naganawa, H et al. (1986) Isolation and properties of valanimycin, a new azoxy antibiotic. J Antibiot (Tokyo) 39:184-91

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