Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Treatment (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CM057201-003
Application #
2300830
Study Section
Project Start
1994-12-01
Project End
1999-11-30
Budget Start
1995-09-14
Budget End
1995-11-30
Support Year
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Ohio State University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
098987217
City
Columbus
State
OH
Country
United States
Zip Code
43210

  Publications

Snapka, R M; Gao, H; Grabowski, D R et al. (2001) Cytotoxic mechanism of XK469: resistance of topoisomerase IIbeta knockout cells and inhibition of topoisomerase I. Biochem Biophys Res Commun 280:1155-60
Huang, K C; Gao, H; Yamasaki, E F et al. (2001) Topoisomerase II poisoning by ICRF-193. J Biol Chem 276:44488-94
Li, Z; Chan, K K (2000) A subnanogram API LC/MS/MS quantitation method for depsipeptide FR901228 and its preclinical pharmacokinetics. J Pharm Biomed Anal 22:33-44
Gao, H; Yamasaki, E F; Chan, K K et al. (2000) Chloroquinoxaline sulfonamide (NSC 339004) is a topoisomerase IIalpha/beta poison. Cancer Res 60:5937-40
Gao, H; Huang, K C; Yamasaki, E F et al. (1999) XK469, a selective topoisomerase IIbeta poison. Proc Natl Acad Sci U S A 96:12168-73
Chan, K K; Bakhtiar, R; Jiang, C (1997) Depsipeptide (FR901228, NSC-630176) pharmacokinetics in the rat by LC/MS/MS. Invest New Drugs 15:195-206