Phase I and Clinical Pharmacokinetic studies on specific investigational new drugs sponsored Division of Cancer Treatment, National Cancer Institute, and Phase II/III studies in patients with disseminated solid tumors and leukemia.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Treatment (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CM057739-008
Application #
3613346
Study Section
Project Start
1985-09-01
Project End
1990-04-30
Budget Start
1989-06-29
Budget End
1989-11-30
Support Year
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Type
Hospitals
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030
Holmes, F A; Valero, V; Walters, R S et al. (1993) The M. D. Anderson Cancer Center experience with Taxol in metastatic breast cancer. J Natl Cancer Inst Monogr :161-9
Pazdur, R; Ajani, J J; Abbruzzese, J L et al. (1992) Phase II evaluation of fluorouracil and recombinant alpha-2a-interferon in previously untreated patients with pancreatic adenocarcinoma. Cancer 70:2073-6
Fossella, F V; Winn, R J; Holoye, P Y et al. (1992) Phase II trial of trimetrexate for unresectable or metastatic non-small cell bronchogenic carcinoma. Invest New Drugs 10:331-5
Pazdur, R; Ajani, J A; Winn, R et al. (1992) A phase II trial of 5-fluorouracil and recombinant alpha-2a-interferon in previously untreated metastatic gastric carcinoma. Cancer 69:878-82
Walters, R S; Theriault, R L; Holmes, F A et al. (1992) Phase II trial of fazarabine (ARA-AC, arabinosyl-5-azacytosine) in metastatic breast cancer. Invest New Drugs 10:43-4
Ho, D H; Brown, N; Lin, J R et al. (1991) Clinical pharmacology of 1-beta-D-arabinofuranosyl-5-azacytosine (fazarabine) following 72-hour infusion. Drug Metab Dispos 19:643-7
Ajani, J A; Pazdur, R; Winn, R J et al. (1991) Phase II study of intravenous 6-thioguanine in patients with advanced gastric carcinoma. Invest New Drugs 9:257-9
Ajani, J A; Pazdur, R; Winn, R J et al. (1991) Phase II study of intravenous 6-thioguanine in patients with advanced carcinoma of the pancreas. Invest New Drugs 9:369-71
Dimery, I W; Brooks, B J; Winn, R et al. (1991) Phase II trial of carboplatin plus cisplatin in recurrent and advanced squamous cell carcinoma of the head and neck. J Clin Oncol 9:1939-44
Ajani, J A; Abbruzzese, J L; Faintuch, J S et al. (1990) A phase II study of trimetrexate therapy for metastatic colorectal carcinoma. Cancer Invest 8:619-21

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