Abstract

Phase I and Clinical Pharmacokinetic studies on specific investigational new drugs sponsored Division of Cancer Treatment, National Cancer Institute, and Phase II/III studies in patients with disseminated solid tumors and leukemia.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Treatment (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CM057739-008
Application #
3613346
Study Section
Project Start
1985-09-01
Project End
1990-04-30
Budget Start
1989-06-29
Budget End
1989-11-30
Support Year
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of Texas MD Anderson Cancer Center
Department
Type
Hospitals
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Holmes, F A; Valero, V; Walters, R S et al. (1993) The M. D. Anderson Cancer Center experience with Taxol in metastatic breast cancer. J Natl Cancer Inst Monogr :161-9
Pazdur, R; Ajani, J A; Winn, R et al. (1992) A phase II trial of 5-fluorouracil and recombinant alpha-2a-interferon in previously untreated metastatic gastric carcinoma. Cancer 69:878-82
Walters, R S; Theriault, R L; Holmes, F A et al. (1992) Phase II trial of fazarabine (ARA-AC, arabinosyl-5-azacytosine) in metastatic breast cancer. Invest New Drugs 10:43-4
Pazdur, R; Ajani, J J; Abbruzzese, J L et al. (1992) Phase II evaluation of fluorouracil and recombinant alpha-2a-interferon in previously untreated patients with pancreatic adenocarcinoma. Cancer 70:2073-6
Fossella, F V; Winn, R J; Holoye, P Y et al. (1992) Phase II trial of trimetrexate for unresectable or metastatic non-small cell bronchogenic carcinoma. Invest New Drugs 10:331-5
Ho, D H; Brown, N; Lin, J R et al. (1991) Clinical pharmacology of 1-beta-D-arabinofuranosyl-5-azacytosine (fazarabine) following 72-hour infusion. Drug Metab Dispos 19:643-7
Ajani, J A; Pazdur, R; Winn, R J et al. (1991) Phase II study of intravenous 6-thioguanine in patients with advanced gastric carcinoma. Invest New Drugs 9:257-9
Ajani, J A; Pazdur, R; Winn, R J et al. (1991) Phase II study of intravenous 6-thioguanine in patients with advanced carcinoma of the pancreas. Invest New Drugs 9:369-71
Dimery, I W; Brooks, B J; Winn, R et al. (1991) Phase II trial of carboplatin plus cisplatin in recurrent and advanced squamous cell carcinoma of the head and neck. J Clin Oncol 9:1939-44
Ajani, J A; Abbruzzese, J L; Faintuch, J S et al. (1990) A phase II study of trimetrexate therapy for metastatic colorectal carcinoma. Cancer Invest 8:619-21

Showing the most recent 10 out of 15 publications