The specific objectives of this project are: (a) to synthesize cogeners of synthetic compounds with confirmed activity; (b) to design and synthesize prodrug; (c) to synthesize compounds related to products of natural origin and other related heterocycles; and (d) to synthesize anti-sense nucleic acids. The Contractor shall provide the synthesis effort necessary to advance novel, but flawed, lead anti-AIDS compounds to clinical candidates and for the synthesis of novel compounds based on biochemical/chemical rationale. Often the initially identified lead compounds are flawed because of poor solubility, insufficient stability, and/or narrow spectrum of activity. The """"""""Congener and Prodrug"""""""" program will permit the synthesis of clinical anti-AIDS candidate compounds by overcoming these various problems. The quantity of compounds to be synthesized will be dictated by the screening needs.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Treatment (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CM087269-002
Application #
3615904
Study Section
Project Start
1988-08-16
Project End
1991-08-15
Budget Start
1989-08-16
Budget End
1990-08-15
Support Year
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Georgia Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
097394084
City
Atlanta
State
GA
Country
United States
Zip Code
30332