The proposed project is a continuation of a project initiated in Finland in 1984 as a collaboration between the U.S. National Cancer Institute and the National Public Health Institute of Finland. The main activity been the Alpha-Tocopherol Beta-Carotene Lung Cancer Prevention Study (ATBC Study), a large randomized, double-blind, placebo-controlled, 2x2 factorial design, primary prevention trial testing the effects of alpha-tocopherol and beta- carotene supplements on lung cancer incidence and mortality. The primary objective of the present project is to follow all living participants in the ATBC Study (N=24,000) during the post-intervention period (1994-2000) to continue to monitor potential intervention effects on lung and other cancers and other morbidity and mortality endpoints. It is plausible that the effects of intervention with such agents will continue several years beyond the immediate period of administration of active agents. Monitoring cancer rates as well as morbidity and mortality from noncancer causes in the post-intervention period will allow us to determine if such effects exist and how long they last. Cancer incidence and all causes of mortality will be determined throughout the proposed 7-year period. Periodic contact with the study population is planned (years 2 and 5) which will permit collection of updated risk factor information including additional biologic specimens in some subjects. Another objective is to study the existing risk factor data and biologic samples for cancer control and causation hypotheses. These data provide an invaluable resource for the study of biochemical and molecular hypotheses. Such analyses will be more informative with the additional cases identified during the continued followup. In summary, the ATBC Study is the largest lung cancer chemoprevention trial ever conducted. Developed and implemented over the pst 10 years, it is an invaluable resource for cancer prevention research. Further follow-up of the 25,000 living participants from this intervention study is of undeniable importance in the field of cancer prevention.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Prevention And Control (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CN045035-003
Application #
3676459
Study Section
Project Start
1994-09-30
Project End
2001-09-29
Budget Start
1996-09-30
Budget End
1997-09-29
Support Year
Fiscal Year
1996
Total Cost
Indirect Cost
Name
National Public Health Institute
Department
Type
DUNS #
City
Helsinki
State
Country
Finland
Zip Code
00300
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Mahabir, Somdat; Leitzmann, Michael F; Virtanen, Mikko J et al. (2005) Prospective study of alcohol drinking and renal cell cancer risk in a cohort of finnish male smokers. Cancer Epidemiol Biomarkers Prev 14:170-5
Mahabir, Somdat; Leitzmann, Michael F; Pietinen, Pirjo et al. (2004) Physical activity and renal cell cancer risk in a cohort of male smokers. Int J Cancer 108:600-5
Paltoo, Dina; Woodson, Karen; Taylor, Philip et al. (2003) Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) gene and risk of prostate cancer among men in a large cancer prevention study. Cancer Lett 191:67-74
Kidd, La Creis R; Woodson, K; Taylor, P R et al. (2003) Polymorphisms in glutathione-S-transferase genes (GST-M1, GST-T1 and GST-P1) and susceptibility to prostate cancer among male smokers of the ATBC cancer prevention study. Eur J Cancer Prev 12:317-20
Mannisto, Satu; Pietinen, Pirjo; Virtanen, Mikko J et al. (2003) Fatty acids and risk of prostate cancer in a nested case-control study in male smokers. Cancer Epidemiol Biomarkers Prev 12:1422-8
Hakkarainen, Reeta; Partonen, Timo; Haukka, Jari et al. (2003) Association of dietary amino acids with low mood. Depress Anxiety 18:89-94

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