The problem of delivering chemopreventive drugs to the target site of action in their unmetabolized, highly concentrated form is an area of research where clearly more attention needs to be focused. In the case of pulmonary tissue, one clear option for drug delivery is the inhalation of aerosols containing chemopreventive agents. Recently the aerosolized administration of budesonide has been shown to markedly inhibit B[a]P induced adenoma formation in lungs of the Strain A mouse. The objective of this workstatement is to investigate the mechanisms and efficacy and explore the strategy of preventing lung cancer by aerosol delivery of chemopreventive agents. The A/J mouse lung adenoma model shall be used with B[a]P, a highly ubiquitous environmental carcinogen found in tobacco smoke, but primarily due to the combustion of fossil fuels. The agent being tested is budesonide. The frequency of lung adenomas per animal is being used as the endpoint in this study. In addition a series of intermediate endpoints including apoptosis, PCNA, micronuclei frequency and ploidy changes are being measured.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Prevention And Control (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CN085148-000
Application #
2849256
Study Section
Project Start
1998-07-07
Project End
2000-06-29
Budget Start
1998-07-07
Budget End
2000-06-29
Support Year
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455