The main objective of this proposal is to obtain comparative data on the response of nonhuman primates to known rodent carcinogens as well as to suspected human carcinogens. Of particular interest is to evaluate in monkeys several chemicals of social and economic importance, such as DDT, saccharin, cyclamate and arsenic. Another objective is to evaluate the long term effects (including carcinogenicity) of antineoplastic agents which currently are in clinical use for primary and adjuvant cancer therapy and for chronic treatment of an increasingly broad spectrum of non-malignant diseases. Other objectives include obtaining tumor model systems in primates for use in testing the effectiveness of new antitumor agents, developing models and strategies for chemoprevention, and developing biological markers and diagnostic tests for early detection of malignant tumors.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CP005622-011
Application #
3626336
Study Section
Project Start
1989-10-30
Project End
1994-10-31
Budget Start
1993-05-07
Budget End
1993-10-31
Support Year
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Covance Laboratories, Inc.
Department
Type
DUNS #
City
Vienna
State
VA
Country
United States
Zip Code
22182