Precancerous Gastric Lesions

You, Wei-Cheng

Abstract

The objectives of this project are to describe and evaluate the determinants of gastric dysplasia and chronic gastritis, conditions thought to be precursors to stomach cancer, in a population in Shandong, China where stomach cancer rates are high. This will be accomplished by a population-based endoscopic survey of 3,000 adults age 35-64 to classify gastric status, with information on diet, tobacco consumption, medical history and other exposures obtained via interviews and measurements of nutrients and other substances in blood, urine, and gastric juice. Rates of transitions of these gastric lesions to cancer will be determined via follow-up of the study population over a 6-year period.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: Division of Cancer Epidemiology And Genetics (NCI)
• Type: Research and Development Contracts (N01)
• Project #: N01CP005631-000
• Application #: 3626413
• Project Start: 1990-10-11
• Budget Start: 1990-10-11
• Budget End: 1991-02-09
• Fiscal Year: 1990

Institution

• Name: Beijing Institute for Cancer Research
• City: Beijing
• Country: China

Publications

Riecken, B; Pfeiffer, R; Ma, J L et al. (2002) No impact of repeated endoscopic screens on gastric cancer mortality in a prospectively followed Chinese population at high risk. Prev Med 34:22-8

Groves, Frank D; Issaq, Haleem; Fox, Stephen et al. (2002) N-nitroso compounds and mutagens in Chinese fermented (sour) corn pancakes. J AOAC Int 85:1052-6

You, W C; Li, J Y; Blot, W J et al. (1999) Evolution of precancerous lesions in a rural Chinese population at high risk of gastric cancer. Int J Cancer 83:615-9

You, W C; Zhang, L; Gail, M H et al. (1998) Precancerous lesions in two counties of China with contrasting gastric cancer risk. Int J Epidemiol 27:945-8

Ma, J L; You, W C; Gail, M H et al. (1998) Helicobacter pylori infection and mode of transmission in a population at high risk of stomach cancer. Int J Epidemiol 27:570-3

You, W C; Zhang, L; Gail, M H et al. (1998) Helicobacter pylori infection, garlic intake and precancerous lesions in a Chinese population at low risk of gastric cancer. Int J Epidemiol 27:941-4

You, W C; Zhang, L; Yang, C S et al. (1996) Nitrite, N-nitroso compounds, and other analytes in physiological fluids in relation to precancerous gastric lesions. Cancer Epidemiol Biomarkers Prev 5:47-52

Zhao, L; Blot, W J; Liu, W D et al. (1994) Familial predisposition to precancerous gastric lesions in a high-risk area of China. Cancer Epidemiol Biomarkers Prev 3:461-4

Zhang, L; Blot, W J; You, W C et al. (1994) Serum micronutrients in relation to pre-cancerous gastric lesions. Int J Cancer 56:650-4

You, W C; Blot, W J; Zhang, L et al. (1993) Serum pepsinogens in relation to precancerous gastric lesions in a population at high risk for gastric cancer. Cancer Epidemiol Biomarkers Prev 2:113-7