The objectives of this project are to continue two randomized controlled intervention trials currently underway in Linxian, a country in north central China with one of the world's highest rate of esophageal cancer. This involves the distribution of NCI-supplied vitamin/mineral pills to 3400 persons with esophageal dysplasia, and to 30,000 in the general population of this high-risk area. All deaths and cancer occurrences among the study populations will be recorded so that mortality and cancer incidence rates between those receiving active pills vs placebo can be contrasted to test the effectiveness of the nutrient supplementation in reducing cancer risk. During this contract year, pill distribution will come to a close, changes in cytologic status of dysplasia patients will be assessed, and treatment group differences in endpoints will be calculated.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CP005634-002
Application #
3626425
Study Section
Project Start
1990-09-28
Project End
1991-09-27
Budget Start
1990-12-01
Budget End
1991-09-27
Support Year
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Chinese Academy of Medical Sciences
Department
Type
DUNS #
City
Beijing
State
Country
China
Zip Code