The University of Minnesota has been under contract to the National Cancer Institute in evaluating the health of workers certified by the American Registry of Radiologic Technologists (ARRT) since February 1982. A 16-page optical scan questionnaire was sent to participants to obtain information on cancer history, risk factors, work history, and personal medical x-ray exposures. Over 90,000 of the 145,000 technologists under study responded to the full-length questionnaire. An additional 14,000 technologists provided information on their history of cancer, myocardial infarction, and thyroid conditions during an abbreviated telephone interview. Reported leukemias and cancers of the breast, thyroid, and lung were validated by obtaining hospital, pathology, and other reports. Computer linkage with the records of the nation's largest commercial dosimetry company has provided at least partial exposure histories on over 85,000 technologists. Additionally, specific exposure information was obtained from employers for persons who developed leukemia, or cancer of the breast, thyroid, or lung as well as for a random sample of the entire cohort. This second survey is being undertaken to obtain detailed information on cancer incidence during the years since the first questionnaire. Occupational and personal exposures to diagnostic x-rays are already coded and crude estimates of whole-body radiation doses can be made. A second follow-up will enable us to link the occurrence of subsequent cancer with these previous measures of radiation exposure. Incident cancers of the breast and thyroid are of particular interest because mortality data are incomplete.
| Bhatti, Parveen; Struewing, Jeffery P; Alexander, Bruce H et al. (2008) Polymorphisms in DNA repair genes, ionizing radiation exposure and risk of breast cancer in U.S. Radiologic technologists. Int J Cancer 122:177-82 |
| Lonn, Stefan; Bhatti, Parveen; Alexander, Bruce H et al. (2007) Papillary thyroid cancer and polymorphic variants in TSHR- and RET-related genes: a nested case-control study within a cohort of U.S. radiologic technologists. Cancer Epidemiol Biomarkers Prev 16:174-7 |
| Doody, Michele Morin; Freedman, D Michal; Alexander, Bruce H et al. (2006) Breast cancer incidence in U.S. radiologic technologists. Cancer 106:2707-15 |
| Freedman, D M; Ron, E; Ballard-Barbash, R et al. (2006) Body mass index and all-cause mortality in a nationwide US cohort. Int J Obes (Lond) 30:822-9 |
| Freedman, D Michal; Sigurdson, Alice J; Rajaraman, Preetha et al. (2006) The mortality risk of smoking and obesity combined. Am J Prev Med 31:355-62 |
| Rajaraman, Preetha; Sigurdson, Alice J; Doody, Michele M et al. (2006) Lung cancer risk among US radiologic technologists, 1983-1998. Int J Cancer 119:2481-6 |
| Linet, Martha S; Hauptmann, Michael; Freedman, D Michal et al. (2006) Interventional radiography and mortality risks in U.S. radiologic technologists. Pediatr Radiol 36 Suppl 2:113-20 |
| Sigurdson, Alice J; Hauptmann, Michael; Alexander, Bruce H et al. (2005) DNA damage among thyroid cancer and multiple cancer cases, controls, and long-lived individuals. Mutat Res 586:173-88 |
| Yoshinaga, Shinji; Hauptmann, Michael; Sigurdson, Alice J et al. (2005) Nonmelanoma skin cancer in relation to ionizing radiation exposure among U.S. radiologic technologists. Int J Cancer 115:828-34 |
| Linet, M S; Freedman, D M; Mohan, A K et al. (2005) Incidence of haematopoietic malignancies in US radiologic technologists. Occup Environ Med 62:861-7 |
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