The objective of this contract are: (1) Resynthesis of polycyclic aromatic hydrocarbon PAH derivatives by established procedures for the restocking of NCI's Chemical Carcinogen Reference Standards Repository as necessary; and (2) Development of synthesis or purification procedures for the preparation of a wide spectrum of selected chemical carcinogens, chemopreventive agents and certain of their metabolites or derivatives.
| Amin, S; Desai, D; Hecht, S S et al. (1996) Synthesis of tobacco-specific N-nitrosamines and their metabolites and results of related bioassays. Crit Rev Toxicol 26:139-47 |
| Page, J E; Szeliga, J; Amin, S et al. (1995) Mutational spectra for 5,6-dimethylchrysene 1,2-dihydrodiol 3,4-epoxides in the supF gene of pSP189. Chem Res Toxicol 8:143-7 |
| Krzeminski, J; Lin, J M; Amin, S et al. (1994) Synthesis of Fjord region diol epoxides as potential ultimate carcinogens of dibenzo[a,l]pyrene. Chem Res Toxicol 7:125-9 |
| Desai, D; Krzeminski, J; Amin, S (1994) Convenient synthesis of 3-methoxybenz[a]anthracene-7,12-dione. Chem Res Toxicol 7:722-3 |
