The objective of this contract is to provide continued follow-up of surviving members of the well-characterized DES-exposed cohorts which will be used to estimate cancer risks in the entire population of approximately 10 million exposed individuals. In addition, existing cohorts will be combined and extended to include previously unstudied exposed individuals in the families, so the total resource will add value to the existing smaller components. Finally, the feasibility of identifying a cohort of grandchildren will be investigated. This work is being supported by the Environmental Epidemiology Branch (EEB), Epidemiology & Biostatistics Program (EBP), Division of Cancer Etiology (DCE) of the National Cancer Institute (NCI).

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CP021168-002
Application #
3627468
Study Section
Project Start
1992-09-30
Project End
Budget Start
1993-05-12
Budget End
1994-09-29
Support Year
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Boston University
Department
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Palmer, Julie R; Herbst, Arthur L; Noller, Kenneth L et al. (2009) Urogenital abnormalities in men exposed to diethylstilbestrol in utero: a cohort study. Environ Health 8:37
Wise, Lauren A; Titus-Ernstoff, Linda; Palmer, Julie R et al. (2007) Time to pregnancy and secondary sex ratio in men exposed prenatally to diethylstilbestrol. Am J Epidemiol 166:765-74
Palmer, Julie R; Wise, Lauren A; Hatch, Elizabeth E et al. (2006) Prenatal diethylstilbestrol exposure and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 15:1509-14
Palmer, Julie R; Wise, Lauren A; Robboy, Stanley J et al. (2005) Hypospadias in sons of women exposed to diethylstilbestrol in utero. Epidemiology 16:583-6
Wise, Lauren A; Palmer, Julie R; Rowlings, Kathleen et al. (2005) Risk of benign gynecologic tumors in relation to prenatal diethylstilbestrol exposure. Obstet Gynecol 105:167-73
Palmer, Julie R; Hatch, Elizabeth E; Rosenberg, Carol L et al. (2002) Risk of breast cancer in women exposed to diethylstilbestrol in utero: prelimiinary results (United States). Cancer Causes Control 13:753-8
Palmer, J R; Hatch, E E; Rao, R S et al. (2001) Infertility among women exposed prenatally to diethylstilbestrol. Am J Epidemiol 154:316-21