The purpose of this contract is to provide support services for the Viral Epidemiology Branch (VEB), Epidemiology and Biostatistics Program (EBP), Division of Cancer Etiology (DCE), National Cancer Institute (NCI) by conducting epidemiologic and natural history studies of hemophiliacs (and persons with related disorders) and their sexual partners and family members; by the maintenance, acquisition and use of epidemiologic data bases; by providing support for collecting and handling biologic specimens and laboratory data; and by statistical analysis of the data.

National Institute of Health (NIH)
Division of Cancer Epidemiology And Genetics (NCI)
Research and Development Contracts (N01)
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Research Triangle Institute
Research Triangle Park
United States
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Katsarou, O; Touloumi, G; Antoniou, A et al. (2005) Progression of HIV infection in the post-HAART era among a cohort of HIV+ Greek haemophilia patients. Haemophilia 11:360-5
Thio, C L; Goedert, J J; Mosbruger, T et al. (2004) An analysis of tumor necrosis factor alpha gene polymorphisms and haplotypes with natural clearance of hepatitis C virus infection. Genes Immun 5:294-300
Hatzakis, Angelos E; Touloumi, Giota; Pantazis, Nikos et al. (2004) Cellular HIV-1 DNA load predicts HIV-RNA rebound and the outcome of highly active antiretroviral therapy. AIDS 18:2261-7
Touloumi, Giota; Pantazis, Nikos; Karafoulidou, Anastasia et al. (2004) Changes in T cell receptor excision DNA circle (TREC) levels in HIV type 1-infected subjects pre- and post-highly active antiretroviral therapy. AIDS Res Hum Retroviruses 20:47-54
Karacki, P S; Gao, X; Thio, C L et al. (2004) MICA and recovery from hepatitis C virus and hepatitis B virus infections. Genes Immun 5:261-6
Khakoo, Salim I; Thio, Chloe L; Martin, Maureen P et al. (2004) HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. Science 305:872-4
Thio, Chloe L; Thomas, David L; Karacki, Peter et al. (2003) Comprehensive analysis of class I and class II HLA antigens and chronic hepatitis B virus infection. J Virol 77:12083-7
Thio, Chloe L; Gao, Xiaojiang; Goedert, James J et al. (2002) HLA-Cw*04 and hepatitis C virus persistence. J Virol 76:4792-7
Goedert, James J; Eyster, M Elaine; Lederman, Michael M et al. (2002) End-stage liver disease in persons with hemophilia and transfusion-associated infections. Blood 100:1584-9
Kostrikis, Leondios G; Touloumi, Giota; Karanicolas, Rose et al. (2002) Quantitation of human immunodeficiency virus type 1 DNA forms with the second template switch in peripheral blood cells predicts disease progression independently of plasma RNA load. J Virol 76:10099-108

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