Recently, the NCI and the Universities of California, San Francisco, and Pennsylvania, completed a case-control study of cutaneous melanoma. The major risk factors for melanoma identified in the preliminary analyses were family history of melanoma and the number of dysplastic nevi. In order to further evaluate these risk factors among the cases and the controls, we have designed a second component of the investigation. The objectives of the current contract are to examine and interview the family members of individuals with familial melanoma for a linkage analysis and to examine and interview the family members of controls with dysplastic nevi for a segregation analysis. A small number of the control families may be used for linkage analysis if the segregation analysis suggests a genetic component of risk. The clinical examination and the interview are unchanged from that used in the original case-control study. This will allow the use of complex segregation and complex linkage analyses to estimate the genetic and environmental components of these risk factors.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CP033045-002
Application #
3628264
Study Section
Project Start
1993-09-30
Project End
1995-06-29
Budget Start
1994-03-31
Budget End
1995-06-29
Support Year
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143