In order to assess the relationship of infection with the human papillomaviruses (HPV) to risk of subsequent cervical neoplasia, a follow- up study of 10,000 women with no evidence of cytologic abnormalities will be conducted. This study will be conducted in a region of Costa Rica that has an incidence rate of cervical cancer approximately 6 times higher than that observed in the United States. At the beginning of this 5-year project, a random sample of the female population within the study region will be identified and recruited for study participation. From each woman, a Pap smear, cervical specimen, blood specimen and personal interview will be obtained. This will allow an examination of risk factors related to prevalent cervical disease. Subsequently, these women will be followed passively through matching identification numbers of subjects against the Costa Rican national cytology and cancer registries. Women with incident cervical abnormalities will be identified and matched with non-cases for subsequent case-control analyses. These analyses will enable the assessment of risk in relation to prior evidence of infection with HPV and other agents, allowing further definition of the natural history of cervical abnormalities. In addition, collected data will enable identification of those factors associated with the progression of low-grade abnormalities to higher grade disease.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CP033061-000
Application #
3628268
Study Section
Project Start
1993-09-30
Project End
Budget Start
1993-09-30
Budget End
1994-09-29
Support Year
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Fundacion Costarricense Para la Docencia
Department
Type
DUNS #
City
San Jose
State
Country
Costa Rica
Zip Code
Porras, Carolina; Wentzensen, Nicolas; Rodríguez, Ana C et al. (2012) Switch from cytology-based to human papillomavirus test-based cervical screening: implications for colposcopy. Int J Cancer 130:1879-87
Clarke, Megan A; Rodriguez, Ana Cecilia; Gage, Julia C et al. (2012) A large, population-based study of age-related associations between vaginal pH and human papillomavirus infection. BMC Infect Dis 12:33
Rodríguez, Ana Cecilia; Schiffman, Mark; Herrero, Rolando et al. (2012) Low risk of type-specific carcinogenic HPV re-appearance with subsequent cervical intraepithelial neoplasia grade 2/3. Int J Cancer 131:1874-81
Castle, Philip E; Rodríguez, Ana Cecilia; Burk, Robert D et al. (2011) Long-term persistence of prevalently detected human papillomavirus infections in the absence of detectable cervical precancer and cancer. J Infect Dis 203:814-22
Rodríguez, Ana Cecilia; García-Piñeres, Alfonso J; Hildesheim, Allan et al. (2011) Alterations of T-cell surface markers in older women with persistent human papillomavirus infection. Int J Cancer 128:597-607
Vaccarella, Salvatore; Franceschi, Silvia; Herrero, Rolando et al. (2011) Clustering of multiple human papillomavirus infections in women from a population-based study in Guanacaste, Costa Rica. J Infect Dis 204:385-90
Smith, Benjamin; Chen, Zigui; Reimers, Laura et al. (2011) Sequence imputation of HPV16 genomes for genetic association studies. PLoS One 6:e21375
Schiffman, Mark; Rodriguez, Ana Cecilia; Chen, Zigui et al. (2010) A population-based prospective study of carcinogenic human papillomavirus variant lineages, viral persistence, and cervical neoplasia. Cancer Res 70:3159-69
Safaeian, Mahboobeh; Quint, Koen; Schiffman, Mark et al. (2010) Chlamydia trachomatis and risk of prevalent and incident cervical premalignancy in a population-based cohort. J Natl Cancer Inst 102:1794-804
Rodriguez, Ana Cecilia; Schiffman, Mark; Herrero, Rolando et al. (2010) Longitudinal study of human papillomavirus persistence and cervical intraepithelial neoplasia grade 2/3: critical role of duration of infection. J Natl Cancer Inst 102:315-24

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