Abstract

Expedite the development of new anticarcinogenic agents. These studies will be linked in large measure to other projects in biological and chemical prevention of carcinogenesis programs, which will provide the agents to be investigated and the means for testing agents for efficacy in anticarcinogenesis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CP041005-003
Application #
3629544
Study Section
Project Start
1984-09-30
Project End
1988-09-29
Budget Start
1986-02-04
Budget End
1987-09-29
Support Year
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Southern Research Institute
Department
Type
DUNS #
006900526
City
Birmingham
State
AL
Country
United States
Zip Code
35205

  Publications

Benbrook, D M; Madler, M M; Spruce, L W et al. (1997) Biologically active heteroarotinoids exhibiting anticancer activity and decreased toxicity. J Med Chem 40:3567-83
Lindamood 3rd, C; Cope, F O; Dillehay, D L et al. (1990) Pharmacological and toxicological properties of arotinoids SMR-2 and SMR-6 in mice. Fundam Appl Toxicol 14:15-29
Lindamood 3rd, C; Mac Thigpen, L; Giles, H D et al. (1989) Modification of retinyl acetate toxicity in rats by coadministration of menhaden oil. Fundam Appl Toxicol 12:567-78
McCarthy, D J; Lindamood 3rd, C; Gundberg, C M et al. (1989) Retinoid-induced hemorrhaging and bone toxicity in rats fed diets deficient in vitamin K. Toxicol Appl Pharmacol 97:300-10
McPhillips, D M; Lindamood 3rd, C; Heath, J E et al. (1988) The disposition and toxicology of retinyl methyl ether in rats dosed orally. Drug Metab Dispos 16:683-9
Lindamood 3rd, C; Giles, H D; Hill, D L (1987) Preliminary toxicity profile of arotinoids SMR-2 and SMR-6 in male B6D2F1 mice. Fundam Appl Toxicol 8:517-30
McCarthy, D J; Lindamood 3rd, C; Hill, D L (1987) Effects of retinoids on metabolizing enzymes and on binding of benzo(a)pyrene to rat tissue DNA. Cancer Res 47:5014-20