Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CP051013-010
Application #
3630882
Study Section
Project Start
1984-11-01
Project End
Budget Start
1989-09-21
Budget End
1989-10-31
Support Year
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Covance Laboratories, Inc.
Department
Type
DUNS #
City
Vienna
State
VA
Country
United States
Zip Code
22182
Snyderwine, E G; Turesky, R J; Turteltaub, K W et al. (1997) Metabolism of food-derived heterocyclic amines in nonhuman primates. Mutat Res 376:203-10
Thorgeirsson, U P; Gomez, D E; Lindsay, C K et al. (1996) Liver tumors and possible preneoplastic lesions, induced by a food-derived heterocyclic amine in cynomolgus monkeys;a study of histology and cytokeratin expression. Liver 16:71-83
Thorgeirsson, U P; Snyderwine, E G; Gomez, D E et al. (1996) Dietary heterocyclic amines as potential human carcinogens: experimental data from nonhuman primates. In Vivo 10:145-52
Dalgard, D W; Thorgeirsson, U P; Adamson, R H (1995) Laparoscopy as a means of monitoring liver tumor induction in nonhuman primates. Princess Takamatsu Symp 23:268-73
Snyderwine, E G; Turesky, R J; Buonarati, M H et al. (1995) Metabolic processing and disposition of 2-amino-3-methylimidazo[4,5-f] quinoline (IQ), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in nonhuman primates. Princess Takamatsu Symp 23:69-77
Adamson, R H; Takayama, S; Sugimura, T et al. (1994) Induction of hepatocellular carcinoma in nonhuman primates by the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline. Environ Health Perspect 102:190-3
Thorgeirsson, U P; Farb, A; Virmani, R et al. (1994) Cardiac damage induced by 2-amino-3-methyl-imidazo[4,5-f]quinoline in nonhuman primates. Environ Health Perspect 102:194-9
Davis, C D; Schut, H A; Adamson, R H et al. (1993) Mutagenic activation of IQ, PhIP and MeIQx by hepatic microsomes from rat, monkey and man: low mutagenic activation of MeIQx in cynomolgus monkeys in vitro reflects low DNA adduct levels in vivo. Carcinogenesis 14:61-5
Snyderwine, E G; Welti, D H; Fay, L B et al. (1992) Metabolism of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in nonhuman primates undergoing carcinogen bioassay. Chem Res Toxicol 5:843-51
Snyderwine, E G; Schut, H A; Adamson, R H et al. (1992) Metabolic activation and genotoxicity of heterocyclic arylamines. Cancer Res 52:2099s-2102s

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