The University of Minnesota has been under contract to the National Cancer Institute in evaluating the health of nearly 145,000 workers certified by the American Registry of Radiologic Technologists since 1982. A comprehensive baseline survey was completed by more than 90,000 technologists between 1984-1989. A second survey is ongoing to obtain detailed information on cancers diagnosed since the first survey. The objectives of this contract are to complete and extend the survey of cancer incidence among U.S. x-ray technologists and to quantify the risk of specific cancers associated with occupational radiation exposures. Extensive application of biological dosimetry techniques will be used to characterize radiation exposures. In addition, the possible role that genetic susceptibility may play in radiation-induced cancers will be evaluated among women who developed breast cancer under the age of 35.
| Bhatti, Parveen; Struewing, Jeffery P; Alexander, Bruce H et al. (2008) Polymorphisms in DNA repair genes, ionizing radiation exposure and risk of breast cancer in U.S. Radiologic technologists. Int J Cancer 122:177-82 |
| Johnson, K J; Alexander, B H; Doody, M M et al. (2008) Childhood cancer in the offspring born in 1921-1984 to US radiologic technologists. Br J Cancer 99:545-50 |
| Lonn, Stefan; Bhatti, Parveen; Alexander, Bruce H et al. (2007) Papillary thyroid cancer and polymorphic variants in TSHR- and RET-related genes: a nested case-control study within a cohort of U.S. radiologic technologists. Cancer Epidemiol Biomarkers Prev 16:174-7 |
| Doody, Michele Morin; Freedman, D Michal; Alexander, Bruce H et al. (2006) Breast cancer incidence in U.S. radiologic technologists. Cancer 106:2707-15 |
| Freedman, D M; Ron, E; Ballard-Barbash, R et al. (2006) Body mass index and all-cause mortality in a nationwide US cohort. Int J Obes (Lond) 30:822-9 |
| Freedman, D Michal; Sigurdson, Alice J; Rajaraman, Preetha et al. (2006) The mortality risk of smoking and obesity combined. Am J Prev Med 31:355-62 |
| Rajaraman, Preetha; Sigurdson, Alice J; Doody, Michele M et al. (2006) Lung cancer risk among US radiologic technologists, 1983-1998. Int J Cancer 119:2481-6 |
| Linet, Martha S; Hauptmann, Michael; Freedman, D Michal et al. (2006) Interventional radiography and mortality risks in U.S. radiologic technologists. Pediatr Radiol 36 Suppl 2:113-20 |
| Linet, M S; Freedman, D M; Mohan, A K et al. (2005) Incidence of haematopoietic malignancies in US radiologic technologists. Occup Environ Med 62:861-7 |
| Sigurdson, Alice J; Hauptmann, Michael; Alexander, Bruce H et al. (2005) DNA damage among thyroid cancer and multiple cancer cases, controls, and long-lived individuals. Mutat Res 586:173-88 |
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