The contract will continue a natural history study of human papillomavirus (HPV) infection and cervical neoplasia. The study has been underway since the early 1990s. The original enrollment was approximately 10,000. We are following selected subcohorts totalling about 6,000 women for specific objectives. Most importantly, we aim to understand better the origins of high-grade squamous intraepithelial lesions (HSIL), the direct precursors to invasive cervical cancer. Cases of HSIL occurring in the cohort will be studied extensively, to understand their origins related to HPV infection. Also, by continuing to study HPV infection on a visual, microscopic, molecular, and serologic level for each woman multiple times, we hope to characterize the natural history of HPV infection in a population. This natural history work is leading to the Phase 3 trial of the NCI HPV vaccine study, scheduled to begin in about 2-3 years. Therefore, we are performing a great deal of methodologic work on the host response to HPV as well.

National Institute of Health (NIH)
Division of Cancer Epidemiology And Genetics (NCI)
Research and Development Contracts (N01)
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Fundacion Costarricense Para la Docencia
San Jose
Costa Rica
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Porras, Carolina; Wentzensen, Nicolas; Rodríguez, Ana C et al. (2012) Switch from cytology-based to human papillomavirus test-based cervical screening: implications for colposcopy. Int J Cancer 130:1879-87
Clarke, Megan A; Rodriguez, Ana Cecilia; Gage, Julia C et al. (2012) A large, population-based study of age-related associations between vaginal pH and human papillomavirus infection. BMC Infect Dis 12:33
Rodríguez, Ana Cecilia; Schiffman, Mark; Herrero, Rolando et al. (2012) Low risk of type-specific carcinogenic HPV re-appearance with subsequent cervical intraepithelial neoplasia grade 2/3. Int J Cancer 131:1874-81
Castle, Philip E; Rodríguez, Ana Cecilia; Burk, Robert D et al. (2011) Long-term persistence of prevalently detected human papillomavirus infections in the absence of detectable cervical precancer and cancer. J Infect Dis 203:814-22
Rodríguez, Ana Cecilia; García-Piñeres, Alfonso J; Hildesheim, Allan et al. (2011) Alterations of T-cell surface markers in older women with persistent human papillomavirus infection. Int J Cancer 128:597-607
Smith, Benjamin; Chen, Zigui; Reimers, Laura et al. (2011) Sequence imputation of HPV16 genomes for genetic association studies. PLoS One 6:e21375
Safaeian, Mahboobeh; Quint, Koen; Schiffman, Mark et al. (2010) Chlamydia trachomatis and risk of prevalent and incident cervical premalignancy in a population-based cohort. J Natl Cancer Inst 102:1794-804
Rodriguez, Ana Cecilia; Schiffman, Mark; Herrero, Rolando et al. (2010) Longitudinal study of human papillomavirus persistence and cervical intraepithelial neoplasia grade 2/3: critical role of duration of infection. J Natl Cancer Inst 102:315-24
González, Paula; Hildesheim, Allan; Rodríguez, Ana Cecilia et al. (2010) Behavioral/lifestyle and immunologic factors associated with HPV infection among women older than 45 years. Cancer Epidemiol Biomarkers Prev 19:3044-54
Cortes, Bernal; Schiffman, Mark; Herrero, Rolando et al. (2010) Establishment and operation of a biorepository for molecular epidemiologic studies in Costa Rica. Cancer Epidemiol Biomarkers Prev 19:916-22

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