The primary objective of this contract is to collect information from cancer patients and population controls in order to increase the statistical power of a current case-control study of cancer risk and drinking water contaminants. In particular, the study conducted under this contract will focus on bladder cancer, which is one of six sites being evaluated in the earlier phase of the study. Results from an earlier investigation (the National Bladder Cancer Study), strongly suggest that certain drinking water contaminants are linked to bladder cancer. The objective of this contract is to gather information, using a mail questionnaire, from an adequate number of bladder cancer patients and a matched group of population controls, to permit evaluation of bladder cancer risk as related to drinking water quality among study subgroups that are exposed, or not exposed, to other bladder cancer risk factors, such as cigarette smoke or occupational carcinogens. Interactive effects of joint exposures will also be evaluated. Information from 900 bladder cancer patients and 900 controls to be collected under this contract will be combined with data gathered from 600 patients and 1500 controls in the earlier phase of the study, for a total of 1500 bladder cancer cases, and 2400 population controls.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CP085614-001
Application #
3634147
Study Section
Project Start
1988-09-30
Project End
1990-09-29
Budget Start
1989-02-16
Budget End
1990-09-29
Support Year
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Iowa
Department
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Ward, Mary H; Rusiecki, Jennifer A; Lynch, Charles F et al. (2007) Nitrate in public water supplies and the risk of renal cell carcinoma. Cancer Causes Control 18:1141-51
Parker, Alexander S; Cerhan, James R; Janney, Carol A et al. (2003) Smoking cessation and renal cell carcinoma. Ann Epidemiol 13:245-51
Zheng, Tongzhang; Cantor, Kenneth P; Zhang, Yawei et al. (2002) Occupation and bladder cancer: a population-based, case-control study in Iowa. J Occup Environ Med 44:685-91
Parker, Alexander S; Cerhan, James R; Lynch, Charles F et al. (2002) Gender, alcohol consumption, and renal cell carcinoma. Am J Epidemiol 155:455-62
Chiu, B C; Lynch, C F; Cerhan, J R et al. (2001) Cigarette smoking and risk of bladder, pancreas, kidney, and colorectal cancers in Iowa. Ann Epidemiol 11:28-37
Cerhan, J R; Putnam, S D; Bianchi, G D et al. (2001) Tea consumption and risk of cancer of the colon and rectum. Nutr Cancer 41:33-40
Cantor, K P; Lynch, C F; Hildesheim, M E et al. (1999) Drinking water source and chlorination byproducts in Iowa. III. Risk of brain cancer. Am J Epidemiol 150:552-60
Cerhan, J R; Parker, A S; Putnam, S D et al. (1999) Family history and prostate cancer risk in a population-based cohort of Iowa men. Cancer Epidemiol Biomarkers Prev 8:53-60
Cerhan, J R; Cantor, K P; Williamson, K et al. (1998) Cancer mortality among Iowa farmers: recent results, time trends, and lifestyle factors (United States). Cancer Causes Control 9:311-9
Cantor, K P; Lynch, C F; Johnson, D (1992) Bladder cancer, parity, and age at first birth. Cancer Causes Control 3:57-62